NCT04135391

Aerobic Trainings on Stroke Patients

Completed NA Last updated 22 October 2019

What this trial tests

NA trial testing Aerobic exercise training in Stroke, Cardiovascular in 23 participants. Completed in 30 June 2018.

Timeline

1 August 2016

Primary endpoint
30 June 2018

30 June 2018

Quick facts

Lead sponsor	Chang Gung Memorial Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	23
Start date	1 August 2016
Primary completion	30 June 2018
Estimated completion	30 June 2018

Drugs / interventions tested

• Aerobic exercise training

Conditions studied

• Stroke, Cardiovascular — all drugs for Stroke, Cardiovascular →

Sponsor

Chang Gung Memorial Hospital

Who can join

Adults 20 to 80, any sex, with Stroke, Cardiovascular. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Effects of different exercise strategies on stroke patients remain unclear. Randomized controlled trial with concealed allocation has been performed from August 1, 2016 to June 30, 2018. We traced back 23 stroke patients, recruited during the above period, aged about 55 years with stroke duration \> 24 months . Intervention: 13 of them underwent 36 times of moderate-intensity continuous training (MICT) at 60% of peak oxygen consumption (VO2peak) for 30 mins, and 10 had high-intensity interval training (HIIT) at alternative 80% and 40% VO2peak with the same training times and duration. Outcome measures: VO2peak, cardiac output (CO), bilateral frontal cortex blood volume (∆\[THb\]), oxyhemoglobin (∆\[O2Hb\]) and deoxyhemoglobin (∆\[HHb\]), ventilation efficiency, serum brain-derived neurotrophic factor (BDNF) levels, cognitive and life quality questionnaire, percentage of neuroblastic cell bearing neurites (% neurites), and cell fluorescent staining were examined before and after interventions.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Increased serum brain-derived neurotrophic factor with high-intensity interval training in stroke patients: A randomized controlled trial.
   Hsu CC, Fu TC, Huang SC, Chen CP, et al · · 2021 · cited 57× · PMID 32344098 · DOI 10.1016/j.rehab.2020.03.010
2. High-intensity interval training versus moderate-intensity continuous training on patient quality of life in cardiovascular disease: a systematic review and meta-analysis.
   Yu H, Zhao X, Wu X, Yang J, et al · · 2023 · cited 27× · PMID 37626066 · DOI 10.1038/s41598-023-40589-5