NCT04123951: ECSERT

Home-based Exercise in Renal Transplant Recipients

Active, enrolled NA Last updated 9 December 2024

What this trial tests

NA trial testing Home-based Exercise in Kidney Transplant; Complications in 50 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

30 January 2020

Primary endpoint
30 June 2027

30 June 2027

Quick facts

Lead sponsor	University of Leicester
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	50
Start date	30 January 2020
Primary completion	30 June 2027
Estimated completion	30 June 2027
Sites	1 location across United Kingdom

Drugs / interventions tested

• Home-based Exercise

Conditions studied

• Kidney Transplant; Complications — all drugs for Kidney Transplant; Complications →

Sponsor

University of Leicester

Who can join

18 and older, any sex, with Kidney Transplant; Complications. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although patients who have received a kidney transplant have better health than patients on dialysis, heart problems are still the commonest cause of death for kidney transplant recipients. This is because diseases like high blood pressure and diabetes are more common in patients with kidney transplants as well as factors related to having kidney disease itself and the medications transplant recipients have to take to stop them rejecting their transplanted kidney. Exercise is known to help with heart disease in lots of conditions and improves many of the risk factors known to cause heart disease in kidney transplant recipients. This study will investigate whether an individualised, home-based, exercise program improves heart disease in kidney transplant recipients. The study is a randomised controlled trial, with half the patients completing the 12 week exercise programme and the other half continuing with their normal care. The investigators will use detailed MRI scans to assess patient's hearts and blood vessels at the start and end of the study. The investigators will also assess changes in physical function, exercise capacity, blood markers of heart disease, changes in body type and quality of life measures assessed with questionnaires.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival.
   Kanbay M, Copur S, Ucku D, Zoccali C. · · 2023 · cited 9× · PMID 36755848 · DOI 10.1093/ckj/sfac216
2. A pilot randomised controlled trial of a structured, home-based exercise programme on cardiovascular structure and function in kidney transplant recipients: the ECSERT study design and methods.
   Billany RE, Vadaszy N, Bishop NC, Wilkinson TJ, et al · · 2021 · cited 6× · PMID 34610929 · DOI 10.1136/bmjopen-2020-046945
3. A structured, home-based exercise programme in kidney transplant recipients (ECSERT): A randomised controlled feasibility study.
   Billany RE, Macdonald JH, Burns S, Chowdhury R, et al · · 2025 · cited 4× · PMID 39992959 · DOI 10.1371/journal.pone.0316031
4. Cardiorespiratory fitness in kidney transplant recipients: A pilot randomised controlled trial of structured home-based rehabilitation and a nested case-control analysis.
   Billany RE, Vadaszy N, Burns S, Chowdhury R, et al · · 2026 · PMID 41468011 · DOI 10.1177/02692155251408792
5. Understanding the feasibility of home-based rehabilitation in kidney transplant recipients: A mixed-methods interpretation.
   Billany RE, Young HML, Lightfoot CJ, Bishop NC, et al · · 2025 · PMID 41417754 · DOI 10.1371/journal.pone.0336620