Last reviewed · How we verify
NCT04122833
Impact of Concomitant Genetic Alterations in EGFR Mutated Adenocarcinoma by NGS Analysis: A Multicenter Study
trial testing Next generation sequencing in Adenocarcinoma of Lung in 80 participants. Status unknown.
30 September 2023
Quick facts
| Lead sponsor | Konkuk University Medical Center |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 30 September 2019 |
| Primary completion | 30 September 2023 |
| Estimated completion | 31 December 2024 |
| Sites | 2 locations across South Korea |
Drugs / interventions tested
- Next generation sequencing
Conditions studied
- Adenocarcinoma of Lung — all drugs for Adenocarcinoma of Lung →
- EGFR Activating Mutation — all drugs for EGFR Activating Mutation →
Sponsor
Konkuk University Medical Center
Who can join
19 and older, any sex, with Adenocarcinoma of Lung or EGFR Activating Mutation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The concomitant co-mutation with epidermal growth factor receptor (EGFR) mutation might influence the clinical outcomes. The investigators will identify the impact of concommitant mutation on clinical outcome in patients with advanced -EGFR mutated adenocarcinoma. The investigators will compare the genetic alterations between tumors of pre and post Tyrosin Kinase Inhibitor(TKI) treatments and predict the resistance mechanism for EGFR-TKIs by next-generation sequencing(NGS) analysis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Variant Allele Frequency Analysis of Circulating Tumor DNA as a Promising Tool in Assessing the Effectiveness of Treatment in Non-Small Cell Lung Carcinoma Patients.
Galant N, Nicoś M, Kuźnar-Kamińska B, Krawczyk P. · · 2024 · cited 9× · PMID 38398173 · DOI 10.3390/cancers16040782
Verify or expand the search:
- PubMed search for NCT04122833
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Next generation sequencing
Trials testing the same drug.
- NCT05811169 — Quest for Tumour Evolution of Non-small Cell Lung Cancer · active not recruiting
- NCT05783973 — Study to Assess the Feasibility in Bile cfDNA of Resectable Biliary Tract Carcinomas · unknown
- NCT05183906 — Evaluation of Next-Generation Sequencing-based Metabarcoding Versus Culturing for Microbiological Assessment in Infectio · unknown
- NCT04689750 — Donor CHIP and Allogeneic HSCT Outcome · recruiting
- NCT05034445 — Whether Sputum Can Serve as an Alternative Source for Liquid Biopsy in Patients With Lung Cancer · completed
Other recruiting trials for Adenocarcinoma of Lung
Currently open trials in the same condition.
- NCT06441357 — Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter · recruiting
- NCT05550961 — APOLLO 11, Consortium of Italian Centers Involved in Treatment of Patients With Lung Cancer Treated With Innovative Ther · recruiting
- NCT04557449 — Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors · Phase 2 · active not recruiting
- NCT04566432 — Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated NSCLC Patients · recruiting
Other Konkuk University Medical Center trials
Trials by the same sponsor.
- NCT06637943 — Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy · not yet recruiting
- NCT06144112 — Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery · Phase 4 · not yet recruiting
- NCT06664320 — Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery · NA · not yet recruiting
- NCT06574594 — Effect of MTX Discontinuation on Shingrix Response in RA · NA · recruiting
- NCT06144099 — Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery · Phase 4 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04122833 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Konkuk University Medical Center
- Last refreshed: 18 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04122833.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing