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NCT04689750
Donor CHIP and Allogeneic HSCT Outcome
trial testing Next generation sequencing in Clonal Hematopoiesis in 850 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | The University of Hong Kong |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 850 |
| Start date | 1 January 2021 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Next generation sequencing
Conditions studied
- Clonal Hematopoiesis — all drugs for Clonal Hematopoiesis →
Sponsor
The University of Hong Kong
Who can join
18 and older, any sex, with Clonal Hematopoiesis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Current data on the impact of donor CHIP on long-term recipient outcome remain largely speculative. Data on the impact of donor CHIP including on allograft function, immunologic dysfunction, graft versus host disease (GVHD), disease relapse and survival across various donor populations are scarce. This is a retrospective-prospective cohort study designed to determine the association between donor gene mutations and outcome following allogeneic HSCT.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections.
Stein A, Metzeler K, Kubasch AS, Rommel KP, et al · · 2022 · cited 25× · PMID 36355225 · DOI 10.1007/s00395-022-00969-w -
Clonal hematopoiesis in myeloid malignancies and solid tumors.
Cai X, Bowman RL, Trowbridge JJ. · · 2025 · cited 3× · PMID 40681796 · DOI 10.1038/s43018-025-01014-0
Verify or expand the search:
- PubMed search for NCT04689750
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Clonal Hematopoiesis
Currently open trials in the same condition.
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- NCT06701214 — The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository · recruiting
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Other The University of Hong Kong trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04689750 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Hong Kong
- Last refreshed: 4 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04689750.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing