NCT04114565: STRING

Prevalence of Major Depression Among Immigrants in Santiago, Chile

Completed Last updated 31 July 2020

What this trial tests

trial in Major Depressive Disorder in 1,092 participants. Completed in 30 June 2020.

Timeline

29 July 2019

Primary endpoint
30 November 2019

30 June 2020

Quick facts

Lead sponsor	Pontificia Universidad Catolica de Chile
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,092
Start date	29 July 2019
Primary completion	30 November 2019
Estimated completion	30 June 2020
Sites	1 location across Chile

Conditions studied

• Major Depressive Disorder — all drugs for Major Depressive Disorder →

Sponsor

Pontificia Universidad Catolica de Chile — full company profile →

Who can join

18 and older, any sex, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile.

The hypotheses are:

1. A healthy immigrant effect will be observed in the studied population by which their prevalence of major depressive disorder will be lower than the prevalence in the general Chilean population.
2. A significant association will be observed between the loss of socio-economic position after migration and a greater probability of major depressive disorder.
3. A significant association will be observed between the report of victimization experience(s) in the previous year and a greater probability of major depressive disorder.
4. A significant association will be observed between financial difficulties and a greater probability of major depressive disorder.

The sampling framework of the Chilean National Institute of Statistics (INE) from the 2016 Census will be used for the purpose of this research. The sampling units are as follows:

1. Primary sampling units (PSUs): conglomerates or groups of adjoining houses, organized in spatial blocks (200 households on average)
2. Secondary sampling units (SSUs): individual households within each of the conglomerates selected in the first stage
3. Final sampling units: persons meeting the study's inclusion criteria Multi-stage random probability sampling involving a 3-stage sampling design will be used - first, the sampling of the primary sampling units (PSUs); second, the sampling of households within the selected PSUs and finally, the random sampling of a household member.

Participants (n=1,100) will then take part in a 45-minute interview. This interview will be a household survey using the modular version of the Composite International Diagnostic Interview (WHO-CIDI) looking at exploring a broad spectrum of factors traditionally associated with increased risk of affective disorders:

1. Sociodemographics
2. Finance
3. Variation in socioeconomic position
4. Experience of victimization
5. Discrimination
6. Experience of childhood adversity

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The Validity and Reliability of the PHQ-9 and PHQ-2 on Screening for Major Depression in Spanish Speaking Immigrants in Chile: A Cross-Sectional Study.
   Errazuriz A, Beltrán R, Torres R, Passi-Solar A. · · 2022 · cited 23× · PMID 36360856 · DOI 10.3390/ijerph192113975