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NCT04113499: DESTIN
Endoscopic Necrosectomy Versus Step-up Endoscopic Intervention
NA trial testing Direct Endoscopic Intervention in Pancreatic Necrosis in 11 participants. Completed in 25 April 2022.
25 April 2022
Quick facts
| Lead sponsor | AdventHealth |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 11 |
| Start date | 27 November 2019 |
| Primary completion | 25 April 2022 |
| Estimated completion | 25 April 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Direct Endoscopic Intervention
- Step-up Endoscopic Intervention
Conditions studied
- Pancreatic Necrosis — all drugs for Pancreatic Necrosis →
- Necrosis Pancreas — all drugs for Necrosis Pancreas →
Sponsor
AdventHealth — full company profile →
Who can join
18 and older, any sex, with Pancreatic Necrosis or Necrosis Pancreas. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This trial is to compare clinical outcomes between patients undergoing immediate endoscopic necrosectomy compared to step-up endoscopic interventions in patients undergoing endoscopic therapy for infected necrotizing pancreatitis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.
Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, et al · · 2024 · cited 48× · PMID 37980922 · DOI 10.1016/s2468-1253(23)00331-x
Verify or expand the search:
- PubMed search for NCT04113499
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pancreatic Necrosis
Currently open trials in the same condition.
- NCT05252897 — Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON) · NA · recruiting
Other AdventHealth trials
Trials by the same sponsor.
- NCT07359352 — Surgical Care And Recovery With Laser Evaluation Trial (SCARLET) · NA · not yet recruiting
- NCT07472127 — Professional Readiness Through Emotional Preparedness (PREP) · NA · not yet recruiting
- NCT07357376 — Evaluating Suzetrigine for Pain Control Following TKA · Phase 3 · not yet recruiting
- NCT07298018 — A Pilot Study of RISE for Nurse Managers Retreat · NA · recruiting
- NCT07081542 — Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04113499 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AdventHealth
- Last refreshed: 12 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04113499.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing