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NCT05252897
Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)
NA trial testing Endoscopic necrosectomy with step up approach in Pancreatic Necrosis in 108 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 108 |
| Start date | 1 February 2022 |
| Primary completion | 31 December 2025 |
| Estimated completion | 30 June 2026 |
| Sites | 9 locations across Hong Kong, South Korea, Thailand, Australia, Spain, India |
Drugs / interventions tested
- Endoscopic necrosectomy with step up approach
- Endoscopic necrosectomy with direct approach
Conditions studied
- Pancreatic Necrosis — all drugs for Pancreatic Necrosis →
Sponsor
Chinese University of Hong Kong
Who can join
18 and older, any sex, with Pancreatic Necrosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Walled-off pancreatic necrosis (WON) is associated with a mortality of 20-30%. The current evidence supports a minimally invasive drainage approach to infected WON. The current suggested approach in international guidelines is the endoscopic step-up approach. However, recent evidence from large national cohorts support the use of direct endoscopic necrosectomy (DEN) at the time of stent placement, resulting in earlier resolution of WON and less number of necrosectomies. This study aims to investigate the clinical outcomes of the DEN versus the step-up approach for necrosectomy after endoscopic drainage of WON.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Time to think prime times for treatment of necrotizing pancreatitis: Pendulum conundrum.
Nakai Y, Hamada T, Saito T, Shiomi H, et al · · 2023 · cited 15× · PMID 37209365 · DOI 10.1111/den.14598
Verify or expand the search:
- PubMed search for NCT05252897
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05252897 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 9 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05252897.
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