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NCT04106427: BrAGG-SoS
Brain Stimulation And Group Therapy to Improve Gesture and Social Skills in Psychosis (BrAGG-SoS)
NA trial testing continuous theta burst stimulation (cTBS) in Schizophrenia in 73 participants. Completed in 24 April 2024.
24 April 2024
Quick facts
| Lead sponsor | University of Bern |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 73 |
| Start date | 1 December 2019 |
| Primary completion | 24 April 2024 |
| Estimated completion | 24 April 2024 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- continuous theta burst stimulation (cTBS)
- placebo cTBS
- social cognitive remediation therapy (SCRT)
- Sham group therapy
Conditions studied
- Schizophrenia — all drugs for Schizophrenia →
Sponsor
University of Bern
Who can join
Adults 18 to 65, any sex, with Schizophrenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Randomized, double-blind, placebo-controlled clinical trial testing the effects of 10 sessions of continuous theta burst stimulation and the effects of 16 sessions of social cognitive remediation therapy on gesture performance and nonverbal communication skills in schizophrenia
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.
Maderthaner L, Pavlidou A, Lefebvre S, Nadesalingam N, et al · · 2023 · cited 16× · PMID 36946525 · DOI 10.1093/schbul/sbac120 -
Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia.
Pavlidou A, Walther S. · · 2020 · cited 12× · PMID 33488466 · DOI 10.3389/fpsyg.2020.607312 -
The Impact of Poor Nonverbal Social Perception on Functional Capacity in Schizophrenia.
Chapellier V, Pavlidou A, Maderthaner L, von Känel S, et al · · 2022 · cited 9× · PMID 35282219 · DOI 10.3389/fpsyg.2022.804093 -
Brain Stimulation and Group Therapy to Improve Gesture and Social Skills in Schizophrenia-The Study Protocol of a Randomized, Sham-Controlled, Three-Arm, Double-Blind Trial.
Chapellier V, Pavlidou A, Mueller DR, Walther S. · · 2022 · cited 8× · PMID 35873264 · DOI 10.3389/fpsyt.2022.909703 -
Using dynamic point light display stimuli to assess gesture deficits in schizophrenia.
Pavlidou A, Chapellier V, Maderthaner L, von Känel S, et al · · 2022 · cited 8× · PMID 35242609 · DOI 10.1016/j.scog.2022.100240 -
Testing a Motor Score Based on PANSS Ratings: A Proxy for Comprehensive Motor Assessment.
Nadesalingam N, Kyrou A, Chapellier V, Maderthaner L, et al · · 2025 · cited 2× · PMID 39222718 · DOI 10.1093/schbul/sbae153 -
Gesture deficits in psychosis and the combination of group psychotherapy and transcranial magnetic stimulation: A randomized clinical trial.
Walther S, Maderthaner L, Chapellier V, von Känel S, et al · · 2025 · PMID 41062802 · DOI 10.1038/s41380-025-03303-7
Verify or expand the search:
- PubMed search for NCT04106427
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04106427 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bern
- Last refreshed: 8 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04106427.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing