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NCT04101968
The GBA Multimodal Study in Parkinson's Disease
trial testing PET scan in Parkinson Disease in 25 participants. Currently enrolling.
30 December 2025
Quick facts
| Lead sponsor | Pacific Parkinson's Research Centre |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 25 |
| Start date | 1 May 2019 |
| Primary completion | 30 December 2025 |
| Estimated completion | 30 December 2025 |
| Sites | 3 locations across Canada, United States |
Drugs / interventions tested
- PET scan — full drug profile →
- neuroQWERTY
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
- GBA Gene Mutation — all drugs for GBA Gene Mutation →
- Gaucher Disease — all drugs for Gaucher Disease →
Sponsor
Pacific Parkinson's Research Centre
Who can join
Adults 18 to 80, any sex, with Parkinson Disease or GBA Gene Mutation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Novel Tracers and Radionuclides in PET Imaging.
Mason C, Gimblet GR, Lapi SE, Lewis JS. · · 2021 · cited 10× · PMID 34392925 · DOI 10.1016/j.rcl.2021.05.012 -
Participant-reported personal utility of genetic testing for Parkinson's disease and interest in clinical trial participation.
Oas H, Cook L, Schwantes-An TH, Walsh LE, et al · · 2024 · cited 3× · PMID 39455611 · DOI 10.1038/s41531-024-00805-z
Verify or expand the search:
- PubMed search for NCT04101968
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Parkinson Disease
Currently open trials in the same condition.
- NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
- NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
- NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
- NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
- NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting
Other Pacific Parkinson's Research Centre trials
Trials by the same sponsor.
- NCT04426786 — Exercise & Brain Energetics in PD · NA · recruiting
- NCT04876404 — Somatotopy in Parkinson's Disease · completed
- NCT03337464 — Single Exercise Bout in Parkinson's Disease (PD) · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04101968 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pacific Parkinson's Research Centre
- Last refreshed: 31 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04101968.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing