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NCT03352037

18F-FDG PET/MR Imaging for Differentiation of Serous From Non-Serous Pancreatic Cystic Neoplasms: A Pilot Study

Completed NA Last updated 19 April 2021
What this trial tests

NA trial testing PET scan in Pancreatic Cystic Neoplasms in 11 participants. Completed in 31 July 2018.

Timeline
15 June 2017
Primary endpoint
31 July 2018
31 July 2018

Quick facts

Lead sponsorUniversity Health Network, Toronto
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposediagnostic
Enrollment11
Start date15 June 2017
Primary completion31 July 2018
Estimated completion31 July 2018
Sites1 location across Canada

Drugs / interventions tested

Conditions studied

Sponsor

University Health Network, Toronto

Who can join

18 and older, any sex, with Pancreatic Cystic Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The overlap of morphological imaging features results in many incidentally detected pancreatic cystic neoplasms going undiagnosed, including benign serous cystic neoplasms (SCN) and potentially malignant mucinous lesions (nonserous). The diagnostic ambiguity then lead to invasive procedures such as endoscopic ultrasonography (EUS), unwarranted surgical resection on SCN lesions or the need for long term periodic surveillance with delayed diagnosis of potentially malignant nonserous lesions. Therefore, precise differentiation of SCN from nonserous cystic neoplasms is highly desirable. The 18F-fluorodeoxyglucose (FDG) accumulation in tumor cells, which is induced by high expression of glucose transporter proteins (mainly include GLUT-1 and -3), can be used to discriminate malignant and benign pancreatic cystic tumors in positron emission tomography (PET) imaging. GLUT-1 expression has also been documented in benign SCN while no such evidence exists in potentially malignant nonserous cystic neoplasms. Based on this evidence, investigators will conduct a pilot study to evaluate if integrated 18F-FDG PET/MR imaging with simultaneous MR and PET acquisition is helpful in differentiation of SCN from nonserous lesions.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. The progress of PET/MRI in clinical management of patients with pancreatic malignant lesions.
    Li J, Fu C, Zhao S, Pu Y, et al · · 2023 · cited 5× · PMID 37188192 · DOI 10.3389/fonc.2023.920896

Verify or expand the search:

Other trials of PET scan

Trials testing the same drug.

Other recruiting trials for Pancreatic Cystic Neoplasms

Currently open trials in the same condition.

Other University Health Network, Toronto trials

Trials by the same sponsor.

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Data sources for this page

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