Last reviewed · How we verify
NCT04095637
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
NA trial testing Medial knee arthroplasty in Unicompartmental Knee Replacement in 140 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | University College, London |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 140 |
| Start date | 24 November 2017 |
| Primary completion | 31 December 2025 |
| Estimated completion | 1 January 2026 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Medial knee arthroplasty
Conditions studied
- Unicompartmental Knee Replacement — all drugs for Unicompartmental Knee Replacement →
- Osteo Arthritis Knee — all drugs for Osteo Arthritis Knee →
- Surgery — all drugs for Surgery →
Sponsor
University College, London
Who can join
Adults 40 to 80, any sex, with Unicompartmental Knee Replacement or Osteo Arthritis Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control. Patients receiving the Mako robotic UKA (Stryker Ltd) will form the investigation group and those undergoing the jig-based Oxford UKA (Zimmer-Biomet Ltd) with navigation control will form the control group. The primary objective in this study is to compare accuracy of component positioning as assessed by postoperative low radiation dose CT scan between conventional Jig-based Oxford UKA with navigation control and Mako robotic UKA.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Robotic-arm assisted medial unicondylar knee arthroplasty versus jig-based unicompartmental knee arthroplasty with navigation control: study protocol for a prospective randomised controlled trial.
Kayani B, Konan S, Tahmassebi J, Ayuob A, et al · · 2020 · cited 3× · PMID 32807219 · DOI 10.1186/s13063-020-04631-5
Verify or expand the search:
- PubMed search for NCT04095637
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04095637 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College, London
- Last refreshed: 9 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04095637.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing