NCT04093518 (EST-S-02) is a Phase 3 clinical trial of Estradiol in Schizophrenia, sponsored by Tangent Data.

Who is sponsoring NCT04093518?

NCT04093518 is sponsored by Tangent Data.

What drugs are being tested in NCT04093518?

Interventions in NCT04093518: Estradiol, Placebo.

What condition does NCT04093518 study?

NCT04093518 studies Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders.

Is NCT04093518 still recruiting?

NCT04093518 is currently status unknown. Last updated 26 May 2020.

Last reviewed 2020-05-26 · How we verify

NCT04093518: EST-S-02

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Estradiol as add-on to Antipsychotics

Status unknown Phase 3 Last updated 26 May 2020

What this trial tests

Phase 3 trial testing Estradiol in Schizophrenia in 100 participants. Status unknown.

Timeline

2 December 2019

Primary endpoint
15 October 2020

1 November 2020

Quick facts

Lead sponsor	Tangent Data
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	100
Start date	2 December 2019
Primary completion	15 October 2020
Estimated completion	1 November 2020
Sites	1 location across Moldova

Drugs / interventions tested

Estradiol (ESTRADIOL) — full drug profile →
Placebo

Conditions studied

Schizophrenia — all drugs for Schizophrenia →
Schizoaffective Disorder — all drugs for Schizoaffective Disorder →
Schizophreniform Disorders — all drugs for Schizophreniform Disorders →

Sponsor

Tangent Data

Who can join

Adults 38 to 48, female only, with Schizophrenia or Schizoaffective Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the study is to evaluate the efficacy of Estradiol patch compared to placebo, as add-on to anti-psychotics in the treatment of women 38 and older with schizophrenia, schizoaffective or schizophreniform disorder.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents.
Correll CU, Solmi M, Cortese S, Fava M, et al · · 2023 · cited 90× · PMID 36640403 · DOI 10.1002/wps.21056

Verify or expand the search:

Other trials of Estradiol

Trials testing the same drug.

NCT05457972 — Postpartum Vaginal Estrogen for Breastfeeding Patients · Phase 4 · recruiting
NCT06253702 — Brain Blood Flow Responses to Stress: Sex Differences · Phase 4 · completed
NCT06005610 — Estradiol Therapy In Transgender Women to Research Interactions With HIV Therapy · Phase 2 · terminated
NCT05617820 — Study Comparing Estradiol Vaginal Inserts 4mcg To IMVEXXY ® (Estradiol Vaginal Inerts 4 mcg) In The Treatment Of Dyspare · Phase 3 · completed
NCT06116201 — Influences of Long Term Hormone Therapy on Physical Fitness and Vascular Function in Transgender Women · NA · completed

Other recruiting trials for Schizophrenia

Currently open trials in the same condition.

NCT07424404 — A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Au · Phase 3 · recruiting
NCT07467993 — Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia · Phase 2 · recruiting
NCT07379827 — Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · recruiting
NCT06758414 — CBT-CP for Veterans With SMI · NA · recruiting
NCT07395206 — Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Dis · NA · recruiting

Other Tangent Data trials

Trials by the same sponsor.

NCT03848234 — Estradiol Patch as add-on to Antipsychotics in Patients With Schizophrenia, Schizoaffective or Schizophreniform Disorder · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04093518 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tangent Data
Last refreshed: 26 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04093518.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing