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NCT04088617
The Effects of Exogenous Ketones on Glucose Tolerance
Phase 1 trial testing Ketone monoester in Dietary Supplement: Ketone Supplement in 20 participants. Completed in 5 January 2020.
30 October 2019
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 20 |
| Start date | 1 August 2019 |
| Primary completion | 30 October 2019 |
| Estimated completion | 5 January 2020 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Ketone monoester
- Placebo
Conditions studied
- Dietary Supplement: Ketone Supplement — all drugs for Dietary Supplement: Ketone Supplement →
- Dietary Supplement: Placebo — all drugs for Dietary Supplement: Placebo →
Sponsor
University of British Columbia
Who can join
Adults 18 to 35, any sex, with Dietary Supplement: Ketone Supplement or Dietary Supplement: Placebo. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04088617
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ketone monoester
Trials testing the same drug.
- NCT07364162 — Exogenous Ketone Supplementation in ICU Delirium · Phase 1 · not yet recruiting
- NCT06053138 — Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More · NA · completed
- NCT05665855 — The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity · NA · completed
- NCT05226962 — The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists · NA · completed
- NCT05294939 — Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists · NA · completed
Other University of British Columbia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04088617 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 24 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04088617.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing