NCT04085237

ESP Block for Laparoscopic Nephrectomy Surgeries

Terminated NA Last updated 16 February 2024

What this trial tests

NA trial testing Ropivacaine injection in Kidney Cancer in 10 participants. Terminated before completion.

Timeline

4 January 2020

Primary endpoint
31 December 2020

16 October 2023

Quick facts

Lead sponsor	McMaster University
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	10
Start date	4 January 2020
Primary completion	31 December 2020
Estimated completion	16 October 2023
Sites	1 location across Canada

Drugs / interventions tested

• Ropivacaine injection — full drug profile →
• Sham

Conditions studied

• Kidney Cancer — all drugs for Kidney Cancer →
• Post-surgical Pain — all drugs for Post-surgical Pain →

Sponsor

McMaster University

Who can join

18 and older, any sex, with Kidney Cancer or Post-surgical Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Nephrectomy (kidney removal) is one of the most common surgical procedures in urologic practice. Recent advances in laparoscopic (keyhole) procedures have resulted in a significant decrease in open nephrectomies. Most laparoscopic surgeries are performed through 3 to 4 small (1 to 1.5 cm) incisions; however, laparoscopic nephrectomies for cancer include one of the incisions being extended to 7 to 10 cm for kidney removal. Although pain after laparoscopic surgery is somewhat less than that after open surgery, it is still significant, and opioid consumption is similar. Opioids have been a mainstay for the treatment of post-operative pain, but they are associated with many adverse effects and a potential for long-term use. Thus, combining opioid analgesia with other forms of analgesia has the potential to reduce opioid use. Paravertebral nerve blocks, where local anesthetic is injected near the spinal nerves, have recently shown good pain control in patients undergoing thoracic and abdominal surgeries. However, this technique is technically challenging, time consuming, and has the risk of significant side effects. Fascial plane blocks are an alternative to paravertebral blocks. Fascial plane blocks, where local anesthetic is injected in areas further away from the spinal nerves, are easier to perform than paravertebral blocks, and have fewer associated risks. A recently described fascial plane block, the Erector Spinae Plane (ESP) block, has been shown to be effective in controlling pain in a variety of surgeries. However, currently, there is little information regarding its use in laparoscopic nephrectomy. We are proposing this pilot randomized control trial to look at the feasibility of completing a larger randomized control trial to evaluate ESP blockade in patients undergoing laparoscopic nephrectomy for cancer. We will also investigate total opioid consumption, and pain scores at rest and during movement.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.