Last reviewed · How we verify
NCT04069169: P-IVLT
IV Lidocaine Analgesia in Pediatric Scoliosis Surgery
Phase 3 trial testing Lidocaine in Scoliosis; Adolescence in 48 participants. Completed in 10 May 2024.
10 May 2024
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | supportive care |
| Enrollment | 48 |
| Start date | 18 December 2019 |
| Primary completion | 10 May 2024 |
| Estimated completion | 10 May 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Lidocaine — full drug profile →
- Saline Solution
Conditions studied
- Scoliosis; Adolescence — all drugs for Scoliosis; Adolescence →
- Anesthesia Recovery Period — all drugs for Anesthesia Recovery Period →
Sponsor
University of British Columbia
Who can join
Adults 10 to 19, any sex, with Scoliosis; Adolescence or Anesthesia Recovery Period. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Surgical correction of scoliosis in children is a long procedure, with an equivalently long recovery time, that is commonly performed at BC Children's Hospital. Treating pain immediately after the procedure is a priority for children during recovery. Morphine is one medication that can be used to manage post-operative pain, but unfortunately, its use is accompanied by a number of side effects which can affect recovery. These include nausea, vomiting, pruritus, sedation, dysphoria, respiratory depression, constipation, ileus, and urinary retention. In order to control pain and reduce morphine consumption, intravenous lidocaine is being investigated. This therapy has been beneficial in adult populations undergoing abdominal surgery and has been associated with decreased post-operative pain, decrease use of opioids including morphine, and ileus. These all contribute to shorter lengths of stay in the hospital and better recovery in the adult population. Intravenous lidocaine is used by some anesthesiologists at BC Children's Hospital to manage post-operative pain in children receiving surgical correction for scoliosis, but this is not a standard of practice. We now propose to conduct a double-blind randomized controlled trial to determine if intravenous lidocaine, infused from start of anesthesia up to 48 hours post-operatively, will reduce morphine use and improve post-operative pain in the pediatric population.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Perioperative Intravenous Lidocaine Infusion Therapy as an Adjunct to Multimodal Analgesia for Adolescent Idiopathic Scoliosis Surgical Correction: A Double-Blind Randomized Controlled Trial.
Luo J, West N, Pang S, Golam A, et al · · 2025 · PMID 40326715 · DOI 10.1111/pan.15124
Verify or expand the search:
- PubMed search for NCT04069169
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other University of British Columbia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04069169 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 14 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04069169.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing