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NCT04068506: GABA
Analgesic Effects of Gabapentin and Paracetamol
Phase 4 trial testing Gabapentin 600 mg Tab in Hand Injuries in 68 participants. Completed in 21 January 2020.
7 January 2020
Quick facts
| Lead sponsor | Dow University of Health Sciences |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 68 |
| Start date | 1 September 2019 |
| Primary completion | 7 January 2020 |
| Estimated completion | 21 January 2020 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Gabapentin 600 mg Tab — full drug profile →
Conditions studied
- Hand Injuries — all drugs for Hand Injuries →
Sponsor
Dow University of Health Sciences
Who can join
Adults 18 to 60, any sex, with Hand Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research is about the effects of drug gabapentin; which is an amino acid that is structurally similar to neurotransmitter GABA. It is a novel drug used for the treatment of postoperative pain with analgesic properties having unique mechanism of action. This study reviews clinical effects of this agent in hand injury patients managed at the Department of Plastics \& Reconstructive Surgery, Dow University of Health Sciences \& Dr. Ruth KM Pfau Civil Hospital Karachi. This study aims to inquire the analgesic properties of gabapentin in the patients and to further investigate its comparison with the equivalent dose of paracetamol given 6 hours after undergoing operative procedure. Acetaminophen is well tolerated when administered in therapeutic dose for pain management. It is a principal drug used as pain reliever and as an antipyretic regimen. This is an experimental study in which a pre-coded questionnaire would be approved in the research for appraising the intensity of pain after intervening operative procedure using visual analogue scale, measuring the pain intensity from 0-10. The questions regarding pain intensity will be inquired after administrating the drug six hours postoperatively. The drug will be prescribed by the doctor on duty having no knowledge regarding the given drug or the group in which he/she is administrating the drug; further questionnaire will be filled by the two co-investigators who will be trained by principal investigator, how to take correct information. Sample size was calculated using www.openepi.com using the previous literature searches of similar research and 50 patients (25 in each group) will be randomly selected from the ward of a known case of hand injury. Group A patients will receive 600 mg of gabapentin post operatively while group B will receive 1 g of paracetamol for management of pain postoperatively orally.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparison of analgesic effects of Gabapentin and Paracetamol post-operatively in patients with hand injury.
Ali H, Naveed, Perveen B. · · 2021 · PMID 34783725 · DOI 10.47391/jpma.359
Verify or expand the search:
- PubMed search for NCT04068506
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hand Injuries
Currently open trials in the same condition.
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- NCT06838247 — Ultrasonographic Analysis of Post-Traumatic Shoulder Lesions After Hand Trauma · recruiting
- NCT05846399 — CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE) · Phase 4 · recruiting
Other Dow University of Health Sciences trials
Trials by the same sponsor.
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- NCT07526818 — Comparison of Manual and Mechanical Glide Path Techniques for Measuring Root Canal Length Using Standalone Apex Locator · NA · active not recruiting
- NCT07433374 — COMPARISON OF THE EFFICIENCY OF MANUAL SINGLE HEADED AND TRIPLE HEADED TOOTHBRUSHES IN REMOVING DENTAL PLAQUE AND USER E · NA · completed
- NCT07277621 — Behavioral Interventions to Reduce Social Media Addiction Among School-Going Adolescents in Karachi · NA · completed
- NCT07323771 — Improving Oral Health Knowledge and Habits in People With Diabetes Through a Theory Guided WhatsApp Education Program · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04068506 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dow University of Health Sciences
- Last refreshed: 27 January 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04068506.
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