Last reviewed · How we verify
NCT04066465: ELBE-ProKids
Neurocognitive Function After Proton Therapy in Children and Adolescents
trial in Primary Brain Tumor in 90 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Technische Universität Dresden |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 1 September 2019 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2027 |
| Sites | 3 locations across Germany |
Conditions studied
- Primary Brain Tumor — all drugs for Primary Brain Tumor →
Sponsor
Technische Universität Dresden — full company profile →
Who can join
Adults 8 to 18, any sex, with Primary Brain Tumor. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in pediatric patients shall be highlighted/analysed/evalutated. In a second step, these results are to be compared with 1. a group of children and adolescents who had only /exclusively had operative therapy and 2. with a healthy control group. Thus, the extent to which these treatment options differ in terms of their short and medium-term effect is assessed. Methods of neurocognitive/neurophysiology brain research approaches are applied that may potentially visualize even small / subtle changes in mental activities/neurocognitive function. Therefore the effects of treatment can be evaluated and the neuropsychological outcome of children and adolescents with brain tumors can be improved.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Proton Beam Therapy for Cancer in Children and Adults: A Health Technology Assessment.
Ontario Health (Quality) . · · 2021 · cited 9× · PMID 34055109
Verify or expand the search:
- PubMed search for NCT04066465
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Technische Universität Dresden trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04066465 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Technische Universität Dresden
- Last refreshed: 6 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04066465.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing