Last reviewed · How we verify
NCT04058457
DBS and Respiration
trial testing DBS in Parkinson Disease in 60 participants. Currently enrolling.
21 July 2026
Quick facts
| Lead sponsor | University of Oxford |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 1 April 2021 |
| Primary completion | 21 July 2026 |
| Estimated completion | 21 September 2026 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- DBS
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
Sponsor
University of Oxford
Who can join
18 and older, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and MRI structural connectivity analysis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Deep brain stimulation of the motor thalamus relieves experimentally induced air hunger.
Chapman TP, Divanbeighi Zand AP, Debrah E, Petric B, et al · · 2024 · cited 5× · PMID 39401855 · DOI 10.1183/13993003.01156-2024
Verify or expand the search:
- PubMed search for NCT04058457
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Parkinson Disease
Currently open trials in the same condition.
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- NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting
Other University of Oxford trials
Trials by the same sponsor.
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- NCT07434973 — Stratification and Treatment in Early Psychosis Study - PROMOTE · Phase 3 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04058457 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Oxford
- Last refreshed: 27 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04058457.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing