NCT04053855 (PEP-C) is a clinical trial of Urinary sample in Clear Cell Renal Cell Carcinoma, sponsored by Centre Hospitalier Universitaire de Saint Etienne.

Who is sponsoring NCT04053855?

NCT04053855 is sponsored by Centre Hospitalier Universitaire de Saint Etienne.

What drugs are being tested in NCT04053855?

Interventions in NCT04053855: Urinary sample.

What condition does NCT04053855 study?

NCT04053855 studies Clear Cell Renal Cell Carcinoma.

Is NCT04053855 still recruiting?

NCT04053855 is currently recruiting now. Last updated 26 October 2024.

Last reviewed 2024-10-26 · How we verify

NCT04053855: PEP-C

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

Recruiting now Last updated 26 October 2024

What this trial tests

trial testing Urinary sample in Clear Cell Renal Cell Carcinoma in 100 participants. Currently enrolling.

Timeline

29 January 2020

Primary endpoint
1 August 2026

1 August 2026

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Saint Etienne
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	100
Start date	29 January 2020
Primary completion	1 August 2026
Estimated completion	1 August 2026
Sites	1 location across France

Drugs / interventions tested

Urinary sample — full drug profile →

Conditions studied

Clear Cell Renal Cell Carcinoma — all drugs for Clear Cell Renal Cell Carcinoma →

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Who can join

18 and older, any sex, with Clear Cell Renal Cell Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Exosome-based immunotherapy: a promising approach for cancer treatment.
Xu Z, Zeng S, Gong Z, Yan Y. · · 2020 · cited 373× · PMID 33183286 · DOI 10.1186/s12943-020-01278-3
Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
Kok VC, Yu CC. · · 2020 · cited 318× · PMID 33116515 · DOI 10.2147/ijn.s272378
Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications.
He G, Peng X, Wei S, Yang S, et al · · 2022 · cited 147× · PMID 35039054 · DOI 10.1186/s12943-021-01440-5
Clinical applications for exosomes: Are we there yet?
Perocheau D, Touramanidou L, Gurung S, Gissen P, et al · · 2021 · cited 101× · PMID 33751579 · DOI 10.1111/bph.15432
Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.
Aheget H, Mazini L, Martin F, Belqat B, et al · · 2020 · cited 75× · PMID 33396739 · DOI 10.3390/cancers13010084
Liquid biopsy at the frontier in renal cell carcinoma: recent analysis of techniques and clinical application.
Li M, Li L, Zheng J, Li Z, et al · · 2023 · cited 57× · PMID 36810071 · DOI 10.1186/s12943-023-01745-7
Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy.
Li Q, Cai S, Li M, Salma KI, et al · · 2021 · cited 31× · PMID 34408415 · DOI 10.2147/ijn.s313912

Verify or expand the search:

Other trials of Urinary sample

Trials testing the same drug.

NCT05551494 — Urinary Concentration of Phthalate Metabolites in Women With and Without Endometriosis · unknown
NCT04025138 — Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains · NA · completed
NCT04014426 — Evaluation of Healthcare Workers Safety During Pressurized Intraperitoneal Aerosol Chemotherapy · NA · completed

Other recruiting trials for Clear Cell Renal Cell Carcinoma

Currently open trials in the same condition.

NCT06863311 — Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear C · Phase 2 · recruiting
NCT07227415 — Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Antica · Phase 1, PHASE2 · recruiting
NCT07187778 — Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal · Phase 2 · recruiting
NCT07389629 — Iparomlimab and Tuvonralimab (QL1706) Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC · Phase 2 · recruiting
NCT06805825 — A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Expres · Phase 1 · recruiting

Other Centre Hospitalier Universitaire de Saint Etienne trials

Trials by the same sponsor.

NCT07326579 — Effects of a Sleep Education Program on the Health Status of Healthcare Workers Working 12-hour Alternating Day-night Sh · NA · not yet recruiting
NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
NCT07483710 — Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission an · NA · not yet recruiting
NCT06845176 — Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery · NA · recruiting
NCT07344298 — Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04053855 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire de Saint Etienne
Last refreshed: 26 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04053855.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing