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NCT04052685
Selective Removal to Soft Dentine vs Selective Removal to Firm Dentine for Deep Posterior Caries Lesions
NA trial testing Selective removal to soft dentin (SRSD) in Deep Caries in 141 participants. Completed in 20 June 2024.
3 March 2020
Quick facts
| Lead sponsor | burcu gözetici |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 141 |
| Start date | 28 November 2018 |
| Primary completion | 3 March 2020 |
| Estimated completion | 20 June 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Selective removal to soft dentin (SRSD)
- Selective removal to firm dentine (SRFD)
Conditions studied
- Deep Caries — all drugs for Deep Caries →
- Pulp Exposure, Dental — all drugs for Pulp Exposure, Dental →
- Dental Caries — all drugs for Dental Caries →
Sponsor
burcu gözetici
Who can join
Adults 13 to 65, any sex, with Deep Caries or Pulp Exposure, Dental. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Removal of infected dentin contaminated with bacteria and remaining affected dentin detected as firm is the conventional strategy for the management of cavitated caries lesions. Recently, this strategy is termed as selective removal to firm dentin (SRFD) and seems to increase the potential risk of pulp exposure or loss of pulp vitality for deep caries lesions radiographically extending ¾ of dentin tissue. Alternatively, selective removal to soft dentine (SRSD) that refers to removal of caries tissue at the periphery of the cavity to firm dentin and remaining caries tissue detected as soft or leathery in proximity with the pulp might be a less invasive excavation method for deep caries lesions to maintain pulpal health. However, information on clinical advantages or disadvantages of SRSD and SRFD excavation methods is sparse and mostly rely on studies conducted for primary teeth. Moreover, clinical trials are needed to demonstrate the combined effect of carious removal strategies and calcium silicate-based materials. The aim of this study is comparison of clinical success rates of SRSD and SRFD techniques in posterior deep caries lesions. The primary outcome of the study is comparison of clinical success of SRSD and SRFD techniques by clinical and radiographic examination after 3 months, 6 months, 1 year and 2 years. The secondary outcome of the study is to investigate whether or not calcium silicate-based materials have an effect on the success rate of the treatment.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Selective removal to soft dentine or selective removal to firm dentine for deep caries lesions ın permanent posterior teeth: a randomized controlled clinical trial up to 2 years.
Gözetici-Çil B, Erdem-Hepşenoğlu Y, Tekin A, Özcan M. · · 2023 · cited 15× · PMID 36460919 · DOI 10.1007/s00784-022-04815-0
Verify or expand the search:
- PubMed search for NCT04052685
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Deep Caries
Currently open trials in the same condition.
- NCT06293521 — Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries · Phase 2 · recruiting
- NCT06683833 — Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Tee · Phase 4 · recruiting
- NCT05816525 — The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious Tissue · recruiting
- NCT06495242 — Direct Pulp Capping Compared to Partial Pulpotomy in Carious Pulp Exposures · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04052685 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by burcu gözetici
- Last refreshed: 21 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04052685.
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