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NCT04046536
rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)
NA trial testing Transcranial Magnetic Stimulation in Gulf War Illness in 204 participants. Completed in 1 December 2025.
30 June 2025
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 204 |
| Start date | 1 October 2019 |
| Primary completion | 30 June 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Transcranial Magnetic Stimulation — full drug profile →
- Sham Transcranial Magnetic Stimulation
Conditions studied
- Gulf War Illness — all drugs for Gulf War Illness →
- Depression — all drugs for Depression →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
Adults 18 to 65, any sex, with Gulf War Illness or Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.
Dickey B, Madhu LN, Shetty AK. · · 2021 · cited 54× · PMID 33164782 · DOI 10.1016/j.pharmthera.2020.107716 -
Repetitive transcranial magnetic stimulation for post-traumatic stress disorder in adults.
Brown R, Cherian K, Jones K, Wickham R, et al · · 2024 · cited 6× · PMID 39092744 · DOI 10.1002/14651858.cd015040.pub2
Verify or expand the search:
- PubMed search for NCT04046536
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Transcranial Magnetic Stimulation
Trials testing the same drug.
- NCT07526285 — Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD) · NA · not yet recruiting
- NCT07050862 — rTMS for Tobacco Use in Veterans · NA · not yet recruiting
- NCT07145866 — Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) · Phase 4 · not yet recruiting
- NCT07516028 — Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia · NA · not yet recruiting
- NCT07389694 — Using Transcranial Magnetic Stimulation to Treat Stuttering · NA · recruiting
Other recruiting trials for Gulf War Illness
Currently open trials in the same condition.
- NCT05820893 — Resistant Potato Starch to Alleviate GWI · Phase 2 · recruiting
- NCT05367245 — Ca-Mg Butyrate in GWI · Phase 2 · recruiting
- NCT05972291 — Mechanisms of Gulf War Illness · NA · recruiting
- NCT05375812 — NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH) · recruiting
- NCT05675878 — Confirmation of Diet as a Treatment for Gulf War Illness · Phase 3 · recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
- NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
- NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04046536 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 18 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04046536.
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