NCT04000880: AMPLIFY

Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health

Active, enrolled NA Last updated 12 June 2025

What this trial tests

NA trial testing Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health in Breast Cancer in 603 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

4 March 2020

Primary endpoint
1 April 2025

1 September 2025

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	supportive care
Enrollment	603
Start date	4 March 2020
Primary completion	1 April 2025
Estimated completion	1 September 2025
Sites	2 locations across United States

Drugs / interventions tested

• Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health
• Diet-Exercise
• Exercise-Diet
• Combined Diet and Exercise

Conditions studied

• Breast Cancer — all drugs for Breast Cancer →
• Colorectal Cancer — all drugs for Colorectal Cancer →
• Endometrial Cancer — all drugs for Endometrial Cancer →
• Kidney Cancer — all drugs for Kidney Cancer →

Sponsor

University of Alabama at Birmingham

Who can join

50 and older, any sex, with Breast Cancer or Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research study will test the efficacy of interactive, web-based interventions that improve diet, physical activity and weight management changes among early stage survivors of breast, prostate, colorectal, endometrial, renal, thyroid, and ovarian cancers, as well as multiple myeloma and non-Hodgkin Lymphoma. Overarching outcomes also include physical function and performance, muscle mass, quality of life, and health utilities.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer.
   Yasin HK, Taylor AH, Ayakannu T. · · 2021 · cited 41× · PMID 33946913 · DOI 10.3390/cancers13092149
2. Dietary interventions for adult cancer survivors.
   Burden S, Jones DJ, Sremanakova J, Sowerbutts AM, et al · · 2019 · cited 41× · PMID 31755089 · DOI 10.1002/14651858.cd011287.pub2
3. Interventions for weight reduction in obesity to improve survival in women with endometrial cancer.
   Agnew H, Kitson S, Crosbie EJ. · · 2023 · cited 16× · PMID 36971688 · DOI 10.1002/14651858.cd012513.pub3
4. Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) cancer survivor health: program project protocols for remote lifestyle intervention and assessment in 3 inter-related randomized controlled trials among survivors of obesity-related cancers.
   Pekmezi D, Fontaine K, Rogers LQ, Pisu M, et al · · 2022 · cited 12× · PMID 35488238 · DOI 10.1186/s12885-022-09519-y
5. Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer.
   Garcia MB, Schadler KL, Chandra J, Clinton SK, et al · · 2023 · cited 11× · PMID 36825928 · DOI 10.3322/caac.21773
6. How Healthy Are the Diets of Cancer Survivors? Characteristics of Those Most at Risk and Opportunities for Improvement.
   Kaur H, Pisu M, Pekmezi DW, Rogers LQ, et al · · 2025 · cited 3× · PMID 40359987 · DOI 10.6004/jnccn.2025.7012
7. Behind the Numbers: Cancer Survivor Recruitment by Demographics and Clinical Status.
   Martin MY, Demark-Wahnefried W, Omairi I, Schoenberger-Godwin YM, et al · · 2026 · PMID 41998846 · DOI 10.1002/cam4.71782
8. Supporting Cancer Survivors in Making Healthful Lifestyle Changes.
   Demark-Wahnefried W, Bail JR, Hoenemeyer T, Pekmezi DW, et al · · 2020 · PMID 41567983 · DOI 10.1080/10463356.2020.1720373