Who is sponsoring NCT03987789?

NCT03987789 is sponsored by University Hospital, Clermont-Ferrand.

What drugs are being tested in NCT03987789?

Interventions in NCT03987789: Driving-pressure-guided group, Low PEEP.

What condition does NCT03987789 study?

NCT03987789 studies Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity.

Is NCT03987789 still recruiting?

NCT03987789 is currently completed. Last updated 31 October 2022.

Last reviewed 2022-10-31 · How we verify

NCT03987789: IMPROVE-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery

Completed NA Last updated 31 October 2022

What this trial tests

NA trial testing Driving-pressure-guided group in Emergency Abdominal Surgery in 707 participants. Completed in 27 October 2022.

Timeline

18 February 2021

Primary endpoint
29 July 2022

27 October 2022

Quick facts

Lead sponsor	University Hospital, Clermont-Ferrand
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	707
Start date	18 February 2021
Primary completion	29 July 2022
Estimated completion	27 October 2022
Sites	28 locations across France

Drugs / interventions tested

Driving-pressure-guided group
Low PEEP

Conditions studied

Emergency Abdominal Surgery — all drugs for Emergency Abdominal Surgery →
Mechanical Ventilation — all drugs for Mechanical Ventilation →
General Anesthesia — all drugs for General Anesthesia →
Postoperative Morbidity — all drugs for Postoperative Morbidity →

Sponsor

University Hospital, Clermont-Ferrand

Who can join

18 and older, any sex, with Emergency Abdominal Surgery or Mechanical Ventilation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at minimizing alveolar distension (low PEEP level without recruitment maneuver) on postoperative respiratory failure and mortality in patients receiving low VT ventilation during emergency abdominal surgery.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial.
Futier E, De Jong A, Cirenei C, Godet T, et al · · 2025 · cited 9× · PMID 40839096 · DOI 10.1007/s00134-025-08082-x
Intraoperative protective mechanical ventilation in patients requiring emergency abdominal surgery: the multicentre prospective randomised IMPROVE-2 study protocol.
Khaled L, Godet T, Jaber S, Chanques G, et al · · 2022 · cited 5× · PMID 35523498 · DOI 10.1136/bmjopen-2021-054823
Correction: Intraoperative protective mechanical ventilation in patients requiring emergency abdominal surgery: the multicentre prospective randomised IMPROVE-2 study protocol.
· 2024 · PMID 39515871 · DOI 10.1136/bmjopen-2021-054823corr1

Verify or expand the search:

Other recruiting trials for Emergency Abdominal Surgery

Currently open trials in the same condition.

NCT07504185 — Physiotherapy After Emergency Laparotomy in the Elderly · NA · recruiting
NCT07047729 — COMPARATIVE OUTCOME OF EARLY AND STANDARD ORAL FEEDING AFTER EMERGENCY BOWEL SURGERY · NA · recruiting

Other University Hospital, Clermont-Ferrand trials

Trials by the same sponsor.

NCT07179276 — Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock · NA · recruiting
NCT07476768 — PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study · NA · not yet recruiting
NCT07439146 — Risk of Pneumonia in Intubated Patients in Emergency Situations · not yet recruiting
NCT07427537 — Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients · NA · recruiting
NCT07330856 — Evaluation of Treatments for Dry or Productive Cough · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03987789 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Clermont-Ferrand
Last refreshed: 31 October 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03987789.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing