Last reviewed · How we verify
NCT03978260: ALICE
Preoperative Anaemia prevaLence In surgiCal patiEnts
trial in Anemia in 2,500 participants. Completed in 31 December 2023.
30 December 2022
Quick facts
| Lead sponsor | Johann Wolfgang Goethe University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 2,500 |
| Start date | 15 August 2019 |
| Primary completion | 30 December 2022 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across Germany |
Conditions studied
- Anemia — all drugs for Anemia →
- Iron-deficiency — all drugs for Iron-deficiency →
- Folic Acid Deficiency — all drugs for Folic Acid Deficiency →
- Vitamin B 12 Deficiency — all drugs for Vitamin B 12 Deficiency →
Sponsor
Johann Wolfgang Goethe University Hospital
Who can join
18 and older, any sex, with Anemia or Iron-deficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Preoperative anaemia is common in surgery, with a prevalence between 10 and 50 %, and is an independent risk factor for morbidity and mortality. Anaemia is mostly the result of an inadequate erythropoiesis due to iron deficiency, lack of vitamin B12 or folate, and bone marrow diseases. Among the elderly, renal disease and chronic inflammation account for approximately one-third of all anaemia incidences. The aim of this study is to provide detailed data about the prevalence of preoperative deficiencies in iron, vitamin B12 and/or folate and the presence of underlying renal or chronic diseases in patients undergoing major surgery.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The aetiology and prevalence of preoperative anaemia in patients undergoing major surgery (ALICE): an international, prospective, observational cohort study.
Choorapoikayil S, Baron DM, Spahn DR, Lasocki S, et al · · 2025 · cited 1× · PMID 41240945 · DOI 10.1016/s2214-109x(25)00320-1 -
The impact of the SARS-CoV-2 pandemic on the ongoing prospective, international, multicentre observational study assessing the preoperative anaemia prevalence in surgical patients (ALICE-trial).
Judd L, Baron DM, Bisbe E, Lasocki S, et al · · 2021 · cited 1× · PMID 34057262 · DOI 10.1111/tme.12792
Verify or expand the search:
- PubMed search for NCT03978260
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Anemia
Currently open trials in the same condition.
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- NCT07315295 — Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya · NA · recruiting
- NCT07400796 — Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia · recruiting
Other Johann Wolfgang Goethe University Hospital trials
Trials by the same sponsor.
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- NCT04975490 — Characterization and Pathogenesis of ACLF · unknown
- NCT04546867 — Establishing a Sonographic Based Algorithm to Verify Pancreatic Stent Position Placed to Prevent Post-ERCP Pancreatitis · NA · completed
- NCT04476498 — Prospective Comparison of Pull-PEG and Pull-PEG With Gastropexy · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03978260 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johann Wolfgang Goethe University Hospital
- Last refreshed: 7 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03978260.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing