NCT03966950 is a NA clinical trial of melatonin in Melatonin, sponsored by University of Sao Paulo.

Who is sponsoring NCT03966950?

NCT03966950 is sponsored by University of Sao Paulo.

What drugs are being tested in NCT03966950?

Interventions in NCT03966950: melatonin, Placebo oral tablet.

What condition does NCT03966950 study?

NCT03966950 studies Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia.

Is NCT03966950 still recruiting?

NCT03966950 is currently status unknown. Last updated 29 May 2019.

Last reviewed 2019-05-29 · How we verify

NCT03966950

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia

Status unknown NA Last updated 29 May 2019

What this trial tests

NA trial testing melatonin in Melatonin in 104 participants. Status unknown.

Timeline

26 June 2017

Primary endpoint
26 November 2019

26 November 2021

Quick facts

Lead sponsor	University of Sao Paulo
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	104
Start date	26 June 2017
Primary completion	26 November 2019
Estimated completion	26 November 2021
Sites	1 location across Brazil

Drugs / interventions tested

melatonin (MELATONIN) — full drug profile →
Placebo oral tablet — full drug profile →

Conditions studied

Melatonin — all drugs for Melatonin →
Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Postoperative Complications — all drugs for Postoperative Complications →
Prostate Hyperplasia — all drugs for Prostate Hyperplasia →

Sponsor

University of Sao Paulo

Who can join

60 and older, male only, with Melatonin or Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Melatonin for preoperative and postoperative anxiety in adults.
Madsen BK, Zetner D, Møller AM, Rosenberg J. · · 2020 · cited 48× · PMID 33319916 · DOI 10.1002/14651858.cd009861.pub3
Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia.
Tavares C, Memória CM, da Costa LGV, Quintão VC, et al · · 2025 · PMID 39729834 · DOI 10.1016/j.clinsp.2024.100562

Verify or expand the search:

Other trials of melatonin

Trials testing the same drug.

NCT06031961 — The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization · NA · unknown
NCT04932096 — Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin · Phase 2 · completed
NCT04530539 — The Effect of Melatonin and Vitamin C on COVID-19 · NA · completed
NCT04235673 — Oral Melatonin as Neuroprotectant in Preterm Infants · NA · completed
NCT03464084 — Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2 · NA · completed

Other recruiting trials for Melatonin

Currently open trials in the same condition.

NCT07344467 — Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery · NA · recruiting
NCT06812026 — Effects of Melatonin and Massage After Third Molar Surgery · active not recruiting
NCT06687304 — Light in Healthcare Environment (Ljus i sjukhusmiljö) · NA · recruiting
NCT06502613 — Idiopathic Scoliosis New Onset and Melatonin Phase Delay in Children · recruiting

Other University of Sao Paulo trials

Trials by the same sponsor.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07522554 — Lavender and Lemongrass Aromatherapy for Pain and Anxiety in Labor: A Randomized Trial · NA · active not recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07445178 — Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopi · completed
NCT07170007 — Physiotherapeutic Protocol Compared to Usual Care in the Treatment of Primiparas After Perineal Trauma · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03966950 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo
Last refreshed: 29 May 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03966950.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing