Who is sponsoring NCT03965702?

NCT03965702 is sponsored by Assistance Publique - Hôpitaux de Paris.

What drugs are being tested in NCT03965702?

Interventions in NCT03965702: Use of a decision support system on the EV1000 monitoring (AFM mode), Manual application of the GDFT protocol (standard of care).

What condition does NCT03965702 study?

NCT03965702 studies Monitoring.

Is NCT03965702 still recruiting?

NCT03965702 is currently completed. Last updated 30 August 2022.

Last reviewed 2022-08-30 · How we verify

NCT03965702: MicroSupport

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of an Assisted Fluid Management System on Microvascular Parameters

Completed NA Last updated 30 August 2022

What this trial tests

NA trial testing Use of a decision support system on the EV1000 monitoring (AFM mode) in Monitoring in 86 participants. Completed in 11 August 2022.

Timeline

13 December 2021

Primary endpoint
10 July 2022

11 August 2022

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	other
Enrollment	86
Start date	13 December 2021
Primary completion	10 July 2022
Estimated completion	11 August 2022
Sites	1 location across France

Drugs / interventions tested

Use of a decision support system on the EV1000 monitoring (AFM mode)
Manual application of the GDFT protocol (standard of care)

Conditions studied

Monitoring — all drugs for Monitoring →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

Adults 18 to 99, any sex, with Monitoring. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will compare a group of patients managed with a manual GDFT protocol (using the EV1000 monitoring device; Edwards Life sciences, Irvine, USA) to a group of patients managed using a novel real time clinical decision support system for goal directed fluid therapy (GDFT) guidance on microvascular parameters in patients undergoing major abdominal or orthopedic surgery.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Assisted Fluid Management and Sublingual Microvascular Flow During High-Risk Abdominal Surgery: A Randomized Controlled Trial.
Coeckelenbergh S, Entzeroth M, Van der Linden P, Flick M, et al · · 2025 · cited 13× · PMID 39116013 · DOI 10.1213/ane.0000000000007097
Decision support guided fluid challenges and stroke volume response during high-risk surgery: a post hoc analysis of a randomized controlled trial.
Coeckelenbergh S, Rinehart J, Desebbe O, Rogoz N, et al · · 2025 · cited 4× · PMID 39826044 · DOI 10.1007/s10877-025-01261-7

Verify or expand the search:

Other recruiting trials for Monitoring

Currently open trials in the same condition.

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NCT06574867 — Evaluation of the viQtor Monitoring Solution on Surgical Wards · recruiting
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Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03965702 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
Last refreshed: 30 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03965702.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing