NCT03958188: POPINET

PreOPerative Imaging of NeuroEndocrine Tumors

Status unknown Last updated 28 May 2019

What this trial tests

trial testing Standardized computerized tomography (CT) reading grid for preoperative planning in Neuro-endocrine Tumors in 47 participants. Status unknown.

Timeline

31 March 2019

Primary endpoint
30 June 2019

31 December 2019

Quick facts

Lead sponsor	Hospices Civils de Lyon
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	47
Start date	31 March 2019
Primary completion	30 June 2019
Estimated completion	31 December 2019
Sites	1 location across France

Drugs / interventions tested

• Standardized computerized tomography (CT) reading grid for preoperative planning

Conditions studied

• Neuro-endocrine Tumors — all drugs for Neuro-endocrine Tumors →
• Small Intestine Cancer — all drugs for Small Intestine Cancer →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

18 and older, any sex, with Neuro-endocrine Tumors or Small Intestine Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Neuro-endocrine tumours (NET) are the most frequent tumours of the small intestine. In spite of their small size, these tumours have the particularity of forming mesenteric metastasis and ganglionic secondary lesions along the superior mesenteric axis, which is in close proximity to the superior mesenteric artery (SMA).

Surgery is the only curative treatment. The complete resection being a factor for good patient prognosis, risks of subsequent local complications (occlusion, bleeding) must be discussed. The limiting factor for resectability is arterial vascular invasion considering the risk of postoperative small bowel syndrome.

At the moment, the choice of imaging examination and its protocol is not standardized, nor the description of the tumoral mesenteric and ganglionic extension, especially the criteria defining a lymph node as lymphadenopathy. In addition, the complexity of SMA's anatomy and the absence of criteria for arterial invasion defining arterial invasion may lead to a misinterpretation of the preoperative imaging , and thus to an incomplete planning of the surgical procedure.

To correct this absence of radiological standardization, the investigating team has developed a reading grid for Computed Tomography (CT) aimed to facilitate preoperative planning of small bowel NET.

The main objective of the current study is to improve the semiotic description of the mesenteric and ganglionic tumoral extension of small intestine NET using a technically optimized imaging examination and a standardized reading grid in order to plan the best surgical procedure which would allow maintaining a minimal length of small intestine needed to yield a satisfying quality of life and nutritional status.

The secondary objective of this study is to evaluate the reproducibility of the standardized scanner's reading grid.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits.
   L'Huillier R, Poncet G, Pasquer A, Walter T, et al · · 2025 · PMID 39949336 · DOI 10.1530/eo-24-0056