NCT03954314 (DEPOSITION) is a Phase 3 clinical trial of Tranexamic Acid in Bleeding, sponsored by Population Health Research Institute.

Who is sponsoring NCT03954314?

NCT03954314 is sponsored by Population Health Research Institute.

What drugs are being tested in NCT03954314?

Interventions in NCT03954314: Tranexamic Acid.

What condition does NCT03954314 study?

NCT03954314 studies Bleeding, Surgical Blood Loss, Seizures.

Is NCT03954314 still recruiting?

NCT03954314 is currently terminated. Last updated 8 December 2023.

Last reviewed 2023-12-08 · How we verify

NCT03954314: DEPOSITION

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery

Terminated Phase 3 Last updated 8 December 2023

What this trial tests

Phase 3 trial testing Tranexamic Acid in Bleeding in 3,242 participants. Terminated before completion.

Timeline

17 September 2019

Primary endpoint
28 November 2023

28 November 2023

Quick facts

Lead sponsor	Population Health Research Institute
Phase	Phase 3
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	3,242
Start date	17 September 2019
Primary completion	28 November 2023
Estimated completion	28 November 2023
Sites	16 locations across New Zealand, Russia, Malaysia, Canada, China, Czechia

Drugs / interventions tested

Tranexamic Acid (Tranexamic Acid) — full drug profile →

Conditions studied

Bleeding — all drugs for Bleeding →
Surgical Blood Loss — all drugs for Surgical Blood Loss →
Seizures — all drugs for Seizures →

Sponsor

Population Health Research Institute

Who can join

18 and older, any sex, with Bleeding or Surgical Blood Loss. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim is to conduct a double-dummy multi-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TxA) versus the usual intravenous TxA in patients undergoing on-pump cardiac surgery.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial.
Lamy A, Sirota DA, Jacques F, Poostizadeh A, et al · · 2024 · cited 16× · PMID 38587333 · DOI 10.1161/circulationaha.124.069606
New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2024.
Tamargo J, Agewall S, Ambrosio G, Borghi C, et al · · 2025 · cited 6× · PMID 40058879 · DOI 10.1093/ehjcvp/pvaf012
Hemostats in the clinic.
Joshi M, Zhao Z, Mitragotri S. · · 2024 · cited 4× · PMID 39545083 · DOI 10.1002/btm2.10673

Verify or expand the search:

Other trials of Tranexamic Acid

Trials testing the same drug.

NCT07501884 — REDUCER Trial (TXA in Urethroplasty) · Phase 4 · not yet recruiting
NCT07460518 — Tranexamic Acid for Bleeding Reduction During TURP Surgery · Phase 4 · not yet recruiting
NCT07390799 — Prophylactic Tranexamic Acid in Low-Risk Repeat Cesarean Delivery: A Randomized Controlled Trial · NA · not yet recruiting
NCT07078942 — Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section · Phase 4 · not yet recruiting
NCT07263841 — Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigme · Phase 2 · active not recruiting

Other recruiting trials for Bleeding

Currently open trials in the same condition.

NCT07401394 — BAR-TAX - Tranexamic Acid in Bariatric Surgery. · NA · active not recruiting
NCT07309848 — Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs · recruiting
NCT07083583 — Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders · recruiting
NCT07019077 — Incidence of Late Haemorrhage After Invasive Gastroenterological Endoscopic Manoeuvre in Patients Treated With Anticoagu · recruiting
NCT07358416 — Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery. · active not recruiting

Other Population Health Research Institute trials

Trials by the same sponsor.

NCT07511543 — Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy · Phase 2 · not yet recruiting
NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
NCT06587737 — Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage · Phase 3 · not yet recruiting
NCT07011095 — DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial · EARLY_PHASE1 · not yet recruiting
NCT06508164 — International CRDS Registry · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03954314 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Population Health Research Institute
Last refreshed: 8 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03954314.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing