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NCT03930446: (DARC)

Alcohol, Behavior, and Brain Imaging

Completed EARLY_PHASE1 Results posted Last updated 25 April 2022
What this trial tests

EARLY_PHASE1 trial testing Ethanol in Alcohol Drinking in 80 participants. Completed in 30 May 2019.

Timeline
1 January 2016
Primary endpoint
30 May 2019
30 May 2019

Quick facts

Lead sponsorUniversity of Chicago
PhaseEARLY_PHASE1
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designcrossover
Maskingdouble
Primary purposebasic science
Enrollment80
Start date1 January 2016
Primary completion30 May 2019
Estimated completion30 May 2019

Drugs / interventions tested

Conditions studied

Sponsor

University of Chicago

Who can join

Adults 21 to 29, any sex, with Alcohol Drinking or Binge Drinking. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Stop Signal Task (SST) Primary · Within an hour post-stimulation condition

The Stop-Signal Task (SST) is a task requiring inhibition of a prepotent motor response. The SST requires participants to respond to a target stimulus as quickly and accurately as possible by pressing a button, but also to withhold their response when they hear an auditory signal. Thus, this task involves a competition between activating and inhibiting processes. The primary outcome variable is change in the stop signal reaction time (SSRT) for the task administered seconds to minutes before and seconds to minutes after stimulation. The theoretical minimum is zero seconds and there is no theor

GroupValue95% CI
Ethanol255± 463
Placebo (Juice)215± 278

Sponsor's own description

To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.
    Li J, Murray CH, Weafer J, de Wit H. · · 2020 · cited 5× · PMID 33201577 · DOI 10.1111/acer.14476

Verify or expand the search:

Other trials of Ethanol

Trials testing the same drug.

Other recruiting trials for Alcohol Drinking

Currently open trials in the same condition.

Other University of Chicago trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03930446.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing