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NCT06091189
Internalized Stress in Relation to Alcohol Consumption
EARLY_PHASE1 trial testing Relevant Trier Social Stressor Test (TSST) in Stress, Physiological in 165 participants. Terminated before completion.
28 February 2025
Quick facts
| Lead sponsor | Texas Tech University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 165 |
| Start date | 12 February 2024 |
| Primary completion | 28 February 2025 |
| Estimated completion | 28 February 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Relevant Trier Social Stressor Test (TSST)
- Ethanol (Ethanol) — full drug profile →
- Placebo Trier Social Stressor Test (TSST)
- Placebo Beverage — full drug profile →
- Irrelevant Trier Social Stressor Test (TSST)
Conditions studied
- Stress, Physiological — all drugs for Stress, Physiological →
- Ethanol Intoxication — all drugs for Ethanol Intoxication →
- Distress, Emotional — all drugs for Distress, Emotional →
Sponsor
Texas Tech University
Who can join
Adults 21 to 29, any sex, with Stress, Physiological or Ethanol Intoxication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed study uses an experimental design to establish causal support for the role of internalized stress, pertaining to uncertainty with regard to one's sexual orientation, in contributing to heavy drinking behavior. Following exposure to internalized sexual stigma, physiological and psychological stress responses are expected to increase alcohol consumption in adults who are uncertain about their sexual orientation, especially among females, and following consumption, the physiological effects of ethanol and beliefs about the effects of alcohol are expected to alter relations between exposure to sexual stigma and the alleviation of psychological distress. Showing that physiological stress responses, whether driven by the pharmacological effects of ethanol or expectancies regarding its effects, can account for known alcohol-use disparities, particularly in bisexual/bi+ communities, would contribute a great deal to knowledge on the biology of addiction and inform subsequent interventions that seek to regulate stress reactivity.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06091189
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Other Texas Tech University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06091189 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Texas Tech University
- Last refreshed: 8 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06091189.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing