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NCT03920150: DO-IT
Vitamin D 24'000 IU for Oral Intermittent Supplementation
Phase 3 trial testing Vitamin D3 in Vitamin D Deficiency in 58 participants. Completed in 31 May 2020.
31 May 2020
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 58 |
| Start date | 30 September 2019 |
| Primary completion | 31 May 2020 |
| Estimated completion | 31 May 2020 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Vitamin D3 (cholecalciferol) — full drug profile →
- Vitamin D oily capsules — full drug profile →
- Vitamin D oily capsules — full drug profile →
Conditions studied
- Vitamin D Deficiency — all drugs for Vitamin D Deficiency →
Sponsor
University Hospital, Basel, Switzerland
Who can join
18 and older, any sex, with Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Vitamin D deficiency (defined as 25(OH)-vitamin D serum level \<50 nmol/l) is cured with oral supplementation. National guidelines recommend the administration of 800 IU cholecalciferol daily for an effective treatment, especially during the winter (poor sun exposition). Cumulative intermittent administration monthly (24'000 IU) or weekly (5'600 IU) is possible. Commercially available intermittent pharmaceutical forms in Switzerland are liquid (oily or alcoholic solution). The study aims to compare the rise of vitamin D3 levels after treatment between newly developed soft capsules and monthly solution (primary outcome), and to evaluate the effect of a loading dose (without infringing the cumulative maximal dose of 4'000 IU per day) on the achievement of optimal values \>75 nmol/l (secondary outcome). The investigators will use newly developed soft capsules and alcoholic solution, which are commercially available in Switzerland.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen.
Rothen JP, Rutishauser J, Walter PN, Hersberger KE, et al · · 2021 · cited 4× · PMID 34548526 · DOI 10.1038/s41598-021-97417-x
Verify or expand the search:
- PubMed search for NCT03920150
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
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Other recruiting trials for Vitamin D Deficiency
Currently open trials in the same condition.
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Other University Hospital, Basel, Switzerland trials
Trials by the same sponsor.
- NCT07444788 — Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants · Phase 1 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03920150 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 4 June 2020
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