NCT03915938 is a Phase 2, PHASE3 clinical trial of Ketamine in Acute Pain, sponsored by Hospital de Clinicas de Porto Alegre.

Who is sponsoring NCT03915938?

NCT03915938 is sponsored by Hospital de Clinicas de Porto Alegre.

What drugs are being tested in NCT03915938?

Interventions in NCT03915938: Ketamine, Placebo.

What condition does NCT03915938 study?

NCT03915938 studies Acute Pain, Chronic Pain, Widespread, Schizophrenia.

Is NCT03915938 still recruiting?

NCT03915938 is currently completed. Last updated 16 April 2019.

Last reviewed 2019-04-16 · How we verify

NCT03915938

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain

Completed Phase 2, PHASE3 Last updated 16 April 2019

What this trial tests

Phase 2, PHASE3 trial testing Ketamine in Acute Pain in 24 participants. Completed in 30 November 2017.

Timeline

2 January 2017

Primary endpoint
30 November 2017

30 November 2017

Quick facts

Lead sponsor	Hospital de Clinicas de Porto Alegre
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	24
Start date	2 January 2017
Primary completion	30 November 2017
Estimated completion	30 November 2017

Drugs / interventions tested

Ketamine (ketamine) — full drug profile →
Placebo

Conditions studied

Acute Pain — all drugs for Acute Pain →
Chronic Pain, Widespread — all drugs for Chronic Pain, Widespread →
Schizophrenia — all drugs for Schizophrenia →

Sponsor

Hospital de Clinicas de Porto Alegre

Who can join

Adults 18 to 40, male only, with Acute Pain or Chronic Pain, Widespread. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a clinical trial that intend to determine the effects of S-ketamine on event-related potentials associated with semantic affective pain-processing

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

S-Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain: A Placebo- Controlled Study in Healthy Male Individuals.
Schwertner A, Zortea M, Torres FV, Ramalho L, et al · · 2019 · cited 1× · PMID 31611759 · DOI 10.3389/fnins.2019.00959

Verify or expand the search:

Other trials of Ketamine

Trials testing the same drug.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT06963294 — Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty · NA · not yet recruiting
NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
NCT06231563 — Ketamine for Veterans With Parkinson's Disease · Phase 2 · recruiting

Other recruiting trials for Acute Pain

Currently open trials in the same condition.

NCT06779604 — Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery · recruiting
NCT07348419 — Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery · NA · recruiting
NCT07335159 — Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention · NA · recruiting
NCT07348523 — Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Sp · NA · recruiting
NCT07336264 — Characterization of Acute Pain · recruiting

Other Hospital de Clinicas de Porto Alegre trials

Trials by the same sponsor.

NCT07469722 — POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure · Phase 2, PHASE3 · not yet recruiting
NCT07264179 — Tracheal Cuff Pressure and Postoperative Complications: A Prospective Observational Study. · not yet recruiting
NCT07052058 — Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to · Phase 2 · not yet recruiting
NCT06953128 — General Versus Regional Anesthesia in Peripheral Arterial Surgery · NA · not yet recruiting
NCT06934707 — Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03915938 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
Last refreshed: 16 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03915938.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing