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NCT03899974
Metabolic Effects of High-amylose Wheat-based Breads
NA trial testing Test meal in Postprandial Hyperglycemia in 20 participants. Completed in 31 July 2019.
15 December 2018
Quick facts
| Lead sponsor | Federico II University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 20 |
| Start date | 1 March 2018 |
| Primary completion | 15 December 2018 |
| Estimated completion | 31 July 2019 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Test meal — full drug profile →
Conditions studied
- Postprandial Hyperglycemia — all drugs for Postprandial Hyperglycemia →
Sponsor
Federico II University
Who can join
Adults 18 to 70, any sex, with Postprandial Hyperglycemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial metabolism. So far, limited evidence is available on the metabolic effect of wheat-based foods rich in amylose. This randomised controlled study investigated the acute metabolic effects of amylose-rich wheat-based breads in overweight subjects focusing on potential mechanisms.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
High Amylose Wheat Bread at Breakfast Increases Plasma Propionate Concentrations and Reduces the Postprandial Insulin Response to the Following Meal in Overweight Adults.
Costabile G, Vetrani C, Calabrese I, Vitale M, et al · · 2023 · cited 6× · PMID 36913446 · DOI 10.1016/j.tjnut.2022.10.007
Verify or expand the search:
- PubMed search for NCT03899974
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other trials of Test meal
Trials testing the same drug.
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- NCT06645756 — Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals · NA · completed
- NCT05207020 — Development and Validation of the Blood Glucose Measurement Device by Air Analysis Expired · NA · completed
- NCT04851327 — Satiation Study With Children Attending a Tertiary Feeding Clinic · NA · completed
- NCT03195062 — Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP) · NA · completed
Other recruiting trials for Postprandial Hyperglycemia
Currently open trials in the same condition.
- NCT06878781 — Postprandial Metabolome and Metabolic Flexibility · NA · recruiting
- NCT06640335 — The Effects of Vegetable Preloading on Postprandial Glycemia, Insulinaemia and Gastric Emptying · NA · active not recruiting
Other Federico II University trials
Trials by the same sponsor.
- NCT07437690 — Fall Prevention in Older Adults in an Italian Cohort · not yet recruiting
- NCT07282132 — Evaluation of Real-World Data on Ropeginterferon Alfa-2b in Patients With Polycythemia Vera: Insights From a Multicenter · not yet recruiting
- NCT07280286 — Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel · NA · not yet recruiting
- NCT07374861 — Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy · recruiting
- NCT07314684 — GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03899974 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Federico II University
- Last refreshed: 4 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03899974.
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