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NCT03894839
Evaluation of the Effect of Different Cleaning and Disinfection Procedures on the Involvement of Candida Species
NA trial testing glutaraldehyde disinfection and microwave application in Candidiasis, Oral in 60 participants. Completed in 22 January 2019.
26 October 2018
Quick facts
| Lead sponsor | Yuzuncu Yil University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 26 October 2017 |
| Primary completion | 26 October 2018 |
| Estimated completion | 22 January 2019 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- glutaraldehyde disinfection and microwave application
- Chlorhexidine gluconate disinfection and microwave application
- Sodium hypochlorite disinfection and microwave application
- glutaraldehyde disinfection and ozone therapy
- Chlorhexidine gluconate disinfection and ozone therapy
- Sodium hypochlorite disinfection and ozone therapy
Conditions studied
- Candidiasis, Oral — all drugs for Candidiasis, Oral →
Sponsor
Yuzuncu Yil University
Who can join
Adults 18 to 70, any sex, with Candidiasis, Oral. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Individuals may experience tooth loss as a result of trauma, periodontal destruction, lack of adequate bone support and clinically dental mobility. The increase in these tooth loss results in a condition called complete toothlessness in patients, and as a result of this, dentists treat complete dentures. It is known that the microorganism retention in the existing restorations is faster and higher than the natural tissues, and this leads to faster plaque build-up and hence bad odor. Candida species are common in oral flora, because they are numerous in the mouth and they are opportunistic pathogenic fungi that can make superficial and deep infections. The most important pathogen species among these parasites is Candida albicans. Mouth moniliasis or acute pseudomembrane candidiasis in the oral cavity of the so-called canker is caused by C.albicans. Chronic hyperplastic candidiasis is a clinical entity that is clinically inseparable from leukoplakia and completely separate from thrush. The accumulation of microorganisms in prosthetic materials is very important for the protection of the health of oral tissues and it is desirable to use appropriate cleaning and disinfection materials to minimize this accumulation. It is known in the literature that ozone and microwave technologies are used as disinfection technique. In this study, the application of ozone and microwave technologies in addition to the cleaning agents used as standard treatment will be compared in vivo. No such research has been found.The aim of this study was to evaluate the effect of different cleaning and disinfection procedures on the involvement of Candida species in complete denture patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03894839
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03894839 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yuzuncu Yil University
- Last refreshed: 29 March 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03894839.
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