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NCT03890406
The Effect of Deep Neuromuscular Blockade on Requirement of Intravenous Anesthetic Agent
NA trial testing Rocuronium: PTC(Post-tetanic count) 1~2 in Laparoscopy in 88 participants. Completed in 31 March 2020.
31 December 2019
Quick facts
| Lead sponsor | Seoul National University Bundang Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 88 |
| Start date | 1 April 2019 |
| Primary completion | 31 December 2019 |
| Estimated completion | 31 March 2020 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Rocuronium: PTC(Post-tetanic count) 1~2 — full drug profile →
- Rocuronium: TOF(Train-of-four) 1~2 — full drug profile →
Conditions studied
- Laparoscopy — all drugs for Laparoscopy →
- General Anesthesia — all drugs for General Anesthesia →
- Neuromuscular Blockade — all drugs for Neuromuscular Blockade →
Sponsor
Seoul National University Bundang Hospital
Who can join
18 and older, any sex, with Laparoscopy or General Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Recently, deep neuromuscular blockade during general anesthesia has been studied by many authors regarding various effects upon patients' outcomes and surgical conditions. We believe deep neuromuscular blockade can be especially beneficial in laparoscopic surgery, because it can expand surgical space and prevent patients' minute movements that can disturb precise operations. In clinical situations, anesthetists tend to compensate the insufficiency of neuromuscular blockade by increasing the dose of other anesthetic agents, which can prolong patients' recovery time and impair the surgical condition. In this study, we plan to divide the patients into 2 groups according to the depth of neuromuscular blockade, and compare the dose of anesthetic agent used to maintain surgical condition.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of depth of neuromuscular blockade on the BIS-guided propofol requirement: A randomized controlled trial.
Nam SW, Oh AY, Koo BW, Kim BY, et al · · 2021 · cited 2× · PMID 34398011 · DOI 10.1097/md.0000000000026576
Verify or expand the search:
- PubMed search for NCT03890406
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03890406 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul National University Bundang Hospital
- Last refreshed: 30 June 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03890406.
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