NCT03880981 is a NA clinical trial of Ibuprofen 600 mg in Musculoskeletal Injury, sponsored by University of California, Los Angeles.

Who is sponsoring NCT03880981?

NCT03880981 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT03880981?

Interventions in NCT03880981: Ibuprofen 600 mg, Acetaminophen.

What condition does NCT03880981 study?

NCT03880981 studies Musculoskeletal Injury.

Is NCT03880981 still recruiting?

NCT03880981 is currently status unknown. Last updated 19 March 2019.

Last reviewed 2019-03-19 · How we verify

NCT03880981

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

NSAID Use and Healing After Tibia Fractures and Achilles Tendon Ruptures

Status unknown NA Last updated 19 March 2019

What this trial tests

NA trial testing Ibuprofen 600 mg in Musculoskeletal Injury in 456 participants. Status unknown.

Timeline

1 August 2019

Primary endpoint
31 July 2020

31 July 2020

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	quadruple
Primary purpose	treatment
Enrollment	456
Start date	1 August 2019
Primary completion	31 July 2020
Estimated completion	31 July 2020

Drugs / interventions tested

Ibuprofen 600 mg — full drug profile →
Acetaminophen (Paracetamol) — full drug profile →

Conditions studied

Musculoskeletal Injury — all drugs for Musculoskeletal Injury →

Sponsor

University of California, Los Angeles

Who can join

18 and older, any sex, with Musculoskeletal Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Rationale: The Emergency Department (ED) typically serves as the front line for patients with acute fractures and tendon ruptures. Pain control for these patients is an essential task of the ED physician. With the advent of the opioid epidemic, ED physicians are becoming more inclined to prescribe non-narcotic pain medications such as non-steroidal anti-inflammatory drugs (NSAIDs). Yet, the effects of NSAIDs on musculoskeletal healing are controversial. The few human studies examining the effects of NSAID use on fracture healing have provided conflicting results. Even less is known about the effects of NSAIDs on tendon healing as this information has largely been gleaned from rodent studies with contradictory findings. There has never been a large, prospective, randomized, double-blinded study to determine the effects of NSAIDs on healing after fractures or tendon ruptures. Here, I propose to pilot the first prospective, randomized, double-blinded study examining the effects of NSAID use on healing after tibia fractures and Achilles tendon ruptures. Aim 1 seeks to determine whether NSAID use is associated with an increased incidence of fracture nonunion and worse functional recovery six months following tibia fractures. I hypothesize that NSAID use after tibia fractures will be associated with an increased incidence of fracture nonunion and worse functional recovery. Aim 2 seeks to determine whether NSAID use is associated with worse functional recovery six months after Achilles tendon ruptures. I hypothesize that NSAID use after Achilles tendon ruptures will be associated with worse functional recovery. Significance: Emergency Department providers commonly prescribe NSAIDs for pain control following fractures and tendon injuries. However, the implications of this practice on bone and tendon healing are unknown. This proposal will pilot the first prospective, randomized, double-blinded study to determine whether NSAID use affects healing after tibia fractures and Achilles tendon ruptures. Results from this study will impact NSAID prescribing patterns for tibia fractures and Achilles tendon ruptures in the ED, either by demonstrating that they impair recovery and should be avoided, or that they need not be withheld as an effective non-narcotic form of pain control.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Ibuprofen 600 mg

Trials testing the same drug.

NCT06937853 — Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management · NA · recruiting
NCT06247462 — Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat · Phase 1 · completed
NCT05548582 — Reduced Opioid Prescription After Laparoscopic Hysterectomy · NA · active not recruiting
NCT05355441 — Pain Multidisciplinar Intervention in Major Trauma Patients · completed
NCT04813991 — Pain Control Without Opioids · Phase 3 · withdrawn

Other recruiting trials for Musculoskeletal Injury

Currently open trials in the same condition.

NCT07145645 — Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children · Phase 3 · recruiting
NCT06925503 — Mind-Body Conditioning Course for University Dance Students · NA · active not recruiting
NCT05989230 — Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma · NA · recruiting
NCT06455969 — Adaptions and Resiliency to Multi-Stressor OpeRations · Phase 4 · recruiting
NCT06046859 — Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma? · Phase 4 · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03880981 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 19 March 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03880981.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing