Adults 18 to 85, any sex, with Hemodialysis or Kidney Failure, Chronic. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
QOL: Kidney Disease Quality of Life (KDQOL36)Primary· 4 weeks
Kidney Disease Quality of Life: Health-related quality of life, with higher scores being better. Minimum is 0, maximum is 100.
Group
Value
95% CI
Twice Weekly Hemodialysis
74
± 17
Thrice Weekly Hemodialysis
72
± 21
Solute ConcentrationSecondary· 4 weeks
Plasma concentration of p-cresol sulfate
Group
Value
95% CI
Twice Weekly Hemodialysis
3.6
2.5 – 4.6
Thrice Weekly Hemodialysis
3.6
2.6 – 4.8
SymptomSecondary· 4 weeks
Dialysis Symptom Index: measures symptom burden on a scale of 0 to 150, with higher scores being worse.
Group
Value
95% CI
Twice Weekly Hemodialysis
26
± 26
Thrice Weekly Hemodialysis
32
± 31
Trail B Making TestSecondary· 4 weeks
Cognitive test: The Trail B Making Test assesses working memory, cognitive flexibility, processing speed, and visual-motor tracking. There are numbers and letters on a page. The participant must connect the number to letter in order. For example, they would start at 1 and draw a line to A, then draw a line to 2, then draw a line to B, then draw a line to 3. The time is recorded in seconds.
Group
Value
95% CI
Twice Weekly Hemodialysis
129
± 73
Thrice Weekly Hemodialysis
125
± 84
Digit Symbol Substitution TestSecondary· 4 weeks
Cognitive test: Digit Symbol Substitution Test, measured in number correct
Group
Value
95% CI
Twice Weekly Hemodialysis
51
± 21
Thrice Weekly Hemodialysis
51
± 20
Sponsor's own description
The study will determine the efficacy of twice weekly hemodialysis in patients with residual kidney function.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07278973 — Hemodiafiltration Versus Hemodialysis in Older People
· NA
· recruiting
NCT07438925 — Copeptin Concentration Measured in Plasma Samples and Intradialytic Blood Pressure Variation
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NCT07234890 — Study to Evaluate the Effects of AV-001 on HD-induced Brain Injury.
· Phase 2
· recruiting
NCT07512895 — The Effect of Progressive Muscle Relaxation Exercises on Depression and Fatigue in Patients Receiving Hemodialysis Treat
· NA
· recruiting
NCT07076888 — Aerobic Exercises and Hemodialysis Patients
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Palo Alto Veterans Institute for Research
Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03874117.