NCT03871244 (P-OpTTICCA) is a Phase 3 clinical trial of Less red blood cell transfusions in Anemia, sponsored by St. Justine's Hospital.

Who is sponsoring NCT03871244?

NCT03871244 is sponsored by St. Justine's Hospital.

What drugs are being tested in NCT03871244?

Interventions in NCT03871244: Less red blood cell transfusions, More red blood cell transfusion (standard transfusion strategy in PICU).

Is NCT03871244 still recruiting?

NCT03871244 is currently status unknown. Last updated 28 September 2021.

Last reviewed 2021-09-28 · How we verify

NCT03871244: P-OpTTICCA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia

Status unknown Phase 3 Last updated 28 September 2021

What this trial tests

Phase 3 trial testing Less red blood cell transfusions in Anemia in 120 participants. Status unknown.

Timeline

3 June 2020

Primary endpoint
31 December 2021

31 December 2022

Quick facts

Lead sponsor	St. Justine's Hospital
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	120
Start date	3 June 2020
Primary completion	31 December 2021
Estimated completion	31 December 2022
Sites	1 location across Canada

Drugs / interventions tested

Less red blood cell transfusions
More red blood cell transfusion (standard transfusion strategy in PICU)

Conditions studied

Anemia — all drugs for Anemia →

Sponsor

St. Justine's Hospital

Who can join

Adults 1 Day to 18, any sex, with Anemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Pilot Optimizing Transfusion Thresholds in Critically-ill Children with Anaemia (P-OpTTICCA) study is a pilot trial for a large pragmatic international parallel open-label non-inferiority randomised controlled trial. The primary outcome of the pilot study is feasibility.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, et al · · 2021 · cited 165× · PMID 34932836 · DOI 10.1002/14651858.cd002042.pub5
Cell therapies in the clinic.
Wang LL, Janes ME, Kumbhojkar N, Kapate N, et al · · 2021 · cited 99× · PMID 34027097 · DOI 10.1002/btm2.10214
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.
Radford M, Estcourt LJ, Sirotich E, Pitre T, et al · · 2024 · cited 8× · PMID 38780066 · DOI 10.1002/14651858.cd011305.pub3
Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.
· 2023 · cited 2× · PMID 37311846 · DOI 10.1186/s13613-023-01131-y
Pilot-Optimizing Transfusion Therapy in Critically Ill Children With Anemia: A Pilot Multicenter Electronic Health Record-Enabled Randomized Controlled Trial on Red Blood Cell Transfusion in Critically Ill Children.
Tucci M, Sarfatti A, Leteurtre S, Du Pont-Thibodeau G, et al · · 2025 · PMID 40938139 · DOI 10.1097/pcc.0000000000003822
43rd International Symposium on Intensive Care & Emergency Medicine
· 2024

Verify or expand the search:

Other recruiting trials for Anemia

Currently open trials in the same condition.

NCT07422480 — A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myel · Phase 3 · recruiting
NCT06968936 — Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy · NA · recruiting
NCT07328191 — Quality of Life-Guided Transfusion in Refractory MDS or AML · NA · recruiting
NCT07315295 — Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya · NA · recruiting
NCT07400796 — Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia · recruiting

Other St. Justine's Hospital trials

Trials by the same sponsor.

NCT04627766 — Validation of Continuous Monitoring of Vital Signs in Children With a Connected Patch · NA · recruiting
NCT06537622 — Best Practices Fo Early Diagnosis of Cerebral Palsy · NA · not yet recruiting
NCT06192368 — Virtual Reality Program to Reduce Stress in Neonatal Nurses · NA · completed
NCT06217510 — Pilot Project on the Automatic Design and 3D Printing of Adolescent Idiopathic Scoliosis Braces (Phase 1) · NA · unknown
NCT06173102 — Cranial Orthosis Therapy for Plagiocephaly: an RCT Pilot Study Comparing Cranial Orthosis to the Natural Course · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03871244 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by St. Justine's Hospital
Last refreshed: 28 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03871244.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing