Who is sponsoring NCT03865069?

NCT03865069 is sponsored by South Tees Hospitals NHS Foundation Trust.

What drugs are being tested in NCT03865069?

Interventions in NCT03865069: Mode of ventilation (Volume Guarantee)®, Mode of ventilation (Volume control Ventilation).

What condition does NCT03865069 study?

NCT03865069 studies Oxygen Saturation Targetting in Preterm Ventilated Infants.

Is NCT03865069 still recruiting?

NCT03865069 is currently completed. Last updated 20 July 2020.

Last reviewed 2020-07-20 · How we verify

NCT03865069: CLIO-VG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Automated Oxygen Control With and Without Automated Pressure Control in Preterm Ventilated Infants.

Completed NA Last updated 20 July 2020

What this trial tests

NA trial testing Mode of ventilation (Volume Guarantee)® in Oxygen Saturation Targetting in Preterm Ventilated Infants in 19 participants. Completed in 12 July 2020.

Timeline

1 November 2019

Primary endpoint
12 July 2020

12 July 2020

Quick facts

Lead sponsor	South Tees Hospitals NHS Foundation Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	19
Start date	1 November 2019
Primary completion	12 July 2020
Estimated completion	12 July 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

Mode of ventilation (Volume Guarantee)®
Mode of ventilation (Volume control Ventilation)

Conditions studied

Oxygen Saturation Targetting in Preterm Ventilated Infants — all drugs for Oxygen Saturation Targetting in Preterm Ventilated Infants →

Sponsor

South Tees Hospitals NHS Foundation Trust

Who can join

Adults 23 Weeks to 36 Weeks, any sex, with Oxygen Saturation Targetting in Preterm Ventilated Infants. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a cross-over randomized study. Eligible participants are preterm infants born at less than 37 weeks gestation (23+0 to 36+6 weeks), who are receiving conventional mechanical ventilation through an endotracheal tube and have a need for supplemental oxygen at the time of enrolment. The planned sample size is 19 subjects completing the study with both arms (38 study periods). The objective of this crossover study is to evaluate the efficacy of the automatic oxygen control function with or without Volume Guarantee®(automatic control of ventilator pressure to deliver the set volume) mode of ventilation in keeping oxygen levels in the safe target range (90 to 95%) in ventilated preterm infants requiring oxygen therapy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison of volume guarantee and volume-controlled ventilation both using closed loop inspired oxygen in preterm infants: a randomised crossover study (CLIO-VG study).
Nair V, Lal MK, Gillone J, Kannan Loganathan P, et al · · 2022 · cited 1× · PMID 34233907 · DOI 10.1136/archdischild-2021-321712

Verify or expand the search:

Other South Tees Hospitals NHS Foundation Trust trials

Trials by the same sponsor.

NCT06705257 — PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY · NA · not yet recruiting
NCT06457815 — Iron Deficiency in Acute Myocardial Infarction: Prevalence Pilot Study · recruiting
NCT05782569 — Serial Lung Ultrasound Predicting Need for Surfactant and Respiratory Course in Preterm Infants Observational Study · unknown
NCT06979687 — Knotless Barbed Suture Closure of the Uterus at Caesarean Section · completed
NCT04687618 — Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support. · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03865069 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by South Tees Hospitals NHS Foundation Trust
Last refreshed: 20 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03865069.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing