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NCT06705257: [PEOPLE]
PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
NA trial testing Studying the effects of varying levels of PEEP using Electrical impedance tomography in PreTerm Neonate in 30 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | South Tees Hospitals NHS Foundation Trust |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 30 |
| Start date | 15 July 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
Drugs / interventions tested
- Studying the effects of varying levels of PEEP using Electrical impedance tomography
Conditions studied
- PreTerm Neonate — all drugs for PreTerm Neonate →
- Positive End Expiratory Pressure (PEEP) — all drugs for Positive End Expiratory Pressure (PEEP) →
- Lung Recruitment — all drugs for Lung Recruitment →
- Electrical Impedance Tomography (EIT) — all drugs for Electrical Impedance Tomography (EIT) →
Sponsor
South Tees Hospitals NHS Foundation Trust
Who can join
Adults 22 Weeks to 32 Weeks, any sex, with PreTerm Neonate or Positive End Expiratory Pressure (PEEP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP/CPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as "continuous distending pressure (CDP)". Those babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung injury . Preterm infants who are already on breathing machine, providing sub optimal PEEP/CPAP could also lead to lung damage. Providing optimal PEEP/CPAP could prevent these negative outcomes. Currently there is not enough evidence to suggest optimal PEEP/CPAP in preterm infants. Neonatal units all around the world uses PEEP/CPAP ranging from 4 to 10cm H20 based on their unit practice. Currently available investigations provide limited one time information (e.g. Chest X-ray) regarding whether baby is receiving optimal PEEP/CPAP. Electrical Impedance Tomography (EIT) is a new technology which could provide better information regarding the pressure delivered. Also, this device would provide continuous information as if the clinicians are doing continuous chest X-ray but without any radiation. In this study, the team will assess the effect of different levels of PEEP/CPAP (4 to 10cm H20) on prevention of lung collapse using EIT. This would be studied in premature infants who are on breathing machine support and CPAP machine support.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06705257
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for PreTerm Neonate
Currently open trials in the same condition.
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- NCT06808997 — Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preter · recruiting
- NCT06632314 — Impact of Enteral Feeding on Splanchnic Oxygenation During Packed Red Blood Cell Transfusion in Preterm Infants · NA · active not recruiting
Other South Tees Hospitals NHS Foundation Trust trials
Trials by the same sponsor.
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- NCT04687618 — Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support. · NA · unknown
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06705257 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by South Tees Hospitals NHS Foundation Trust
- Last refreshed: 16 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06705257.
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