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NCT03859297: RuMeChange
Mechanisms of Rumination Change in Adolescent Depression
NA trial testing Rumination-Focused CBT in Major Depressive Disorder in 183 participants. Currently enrolling.
14 April 2028
Quick facts
| Lead sponsor | Ohio State University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 183 |
| Start date | 1 May 2019 |
| Primary completion | 14 April 2028 |
| Estimated completion | 2 March 2029 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Rumination-Focused CBT
- Relaxation-based Therapy
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Mood Disorders — all drugs for Mood Disorders →
Sponsor
Ohio State University
Who can join
Adults 14 to 17, any sex, with Major Depressive Disorder or Mood Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Mechanisms of rumination change in adolescent depression (RuMeChange): study protocol for a randomised controlled trial of rumination-focused cognitive behavioural therapy to reduce ruminative habit and risk of depressive relapse in high-ruminating adolescents.
Roberts H, Jacobs RH, Bessette KL, Crowell SE, et al · · 2021 · cited 22× · PMID 33892684 · DOI 10.1186/s12888-021-03193-3 -
Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.
Langenecker SA, Westlund Schreiner M, Bessette KL, Roberts H, et al · · 2024 · cited 14× · PMID 38021251 · DOI 10.1016/j.bpsgos.2023.08.012 -
State rumination predicts inhibitory control failures and dysregulation of default, salience, and cognitive control networks in youth at risk of depressive relapse: Findings from the RuMeChange trial.
Roberts H, Schreiner MW, Pocius S, Dillahunt AK, et al · · 2024 · cited 3× · PMID 38769946 · DOI 10.1016/j.jadr.2024.100729 -
Rumination induction task in fMRI: Effects of rumination focused cognitive behavioral therapy and stability in youth.
Westlund Schreiner M, Jacobsen AM, Farstead BW, Miller RH, et al · · 2025 · cited 2× · PMID 39701467 · DOI 10.1016/j.jad.2024.12.056 -
Self-Injury in Adolescence Is Associated with Greater Behavioral Risk Avoidance, Not Risk-Taking.
Dillahunt AK, Feldman DA, Thomas LR, Farstead BW, et al · · 2022 · cited 2× · PMID 35268378 · DOI 10.3390/jcm11051288 -
Caregiver-Child Co-Rumination and Treatment Outcomes in a Randomized Clinical Trial of Rumination-Focused Cognitive-Behavioral Therapy.
Kaufman EA, Xu Y, Farstead B, Schreiner MW, et al · · 2025 · PMID 41458014 · DOI 10.14302/issn.2476-1710.jdt-25-5775
Verify or expand the search:
- PubMed search for NCT03859297
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03859297 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ohio State University
- Last refreshed: 11 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03859297.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing