Last reviewed · How we verify
NCT03858387
PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients
trial testing Meropenem in Critical Illness in 102 participants. Status unknown.
31 December 2020
Quick facts
| Lead sponsor | Prince of Songkla University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 102 |
| Start date | 1 September 2018 |
| Primary completion | 31 December 2020 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
Conditions studied
- Critical Illness — all drugs for Critical Illness →
- Bacterial Infections — all drugs for Bacterial Infections →
Sponsor
Prince of Songkla University
Who can join
18 and older, any sex, with Critical Illness or Bacterial Infections. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Meropenem and imipenem are broad-spectrum carbapenem antibiotic and are frequently prescribed in critically ill patients with severe infections. These patients show several pathophysiological changes that may alter the carbapenem pharmacokinetic (PK) normally found in other populations. Although the PK of carbapenems has been widely studied, most studies have been conducted on small populations, and clinical outcome data are sparse. Therefore, the aims of this study are (i) describe the population pharmacokinetic parameters of meropenem and imipenem in critically ill subject (ii) evaluate the pharmacodynamic of meropenem and imipenem as a predictor of clinical treatment outcome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
NONMEM population pharmacokinetics and Monte Carlo dosing simulations of imipenem in critically ill patients with life-threatening severe infections during support with or without extracorporeal membrane oxygenation in an intensive care unit.
Jaruratanasirikul S, Boonpeng A, Nawakitrangsan M, Samaeng M. · · 2021 · cited 10× · PMID 34080708 · DOI 10.1002/phar.2597
Verify or expand the search:
- PubMed search for NCT03858387
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Meropenem
Trials testing the same drug.
- NCT06184659 — Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis · Phase 4 · recruiting
- NCT07445282 — This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Me · Phase 4 · completed
- NCT06916156 — Evaluation of the Concentration of ANT3310 and Meropenem in the Lung in Healthy Adult Participants · Phase 1 · completed
- NCT06527677 — Assessment of the Pharmacokinetics and Safety of ANT3310 Combined With Meropenem in Renally Impaired Subjects · Phase 1 · completed
- NCT05905913 — FiH Study to Assess Safety and PK of SAD and MAD of ANT3310 Alone and in Combination With Meropenem in Healthy Subjects · Phase 1 · completed
Other recruiting trials for Critical Illness
Currently open trials in the same condition.
- NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
- NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
- NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
- NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
- NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
Other Prince of Songkla University trials
Trials by the same sponsor.
- NCT06841133 — Chinese Art Activities or Combined With Peer Group Participation on Psychological Well Being · NA · not yet recruiting
- NCT06837116 — Immunogenicity of an Intradermal Qdenga Vaccine Among Healthy Volunteers · EARLY_PHASE1 · completed
- NCT06476652 — Effect of Simple Simulator-based Training on Initial Performance of Novices Iultrasound-guided Adductor Canal Block · enrolling by invitation
- NCT07245966 — Pharmacokinetics and Pharmacodynamics of High Dose Ceftriaxone in Patients With Sepsis · completed
- NCT06265870 — Specific Versus Empirical Anthelminthic Treatment in Eosinophilia · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03858387 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Prince of Songkla University
- Last refreshed: 1 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03858387.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing