NCT03854825 (NEPAKI-CS) is a clinical trial of Cardiac surgery in Acute Kidney Injury, sponsored by Medical University of Vienna.

Who is sponsoring NCT03854825?

NCT03854825 is sponsored by Medical University of Vienna.

What drugs are being tested in NCT03854825?

Interventions in NCT03854825: Cardiac surgery.

What condition does NCT03854825 study?

NCT03854825 studies Acute Kidney Injury.

Is NCT03854825 still recruiting?

NCT03854825 is currently completed. Last updated 22 April 2019.

Last reviewed 2019-04-22 · How we verify

NCT03854825: NEPAKI-CS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery

Completed Last updated 22 April 2019

What this trial tests

trial testing Cardiac surgery in Acute Kidney Injury in 100 participants. Completed in 1 April 2019.

Timeline

30 October 2016

Primary endpoint
25 January 2018

1 April 2019

Quick facts

Lead sponsor	Medical University of Vienna
Status	Completed
Study type	OBSERVATIONAL
Enrollment	100
Start date	30 October 2016
Primary completion	25 January 2018
Estimated completion	1 April 2019
Sites	1 location across Austria

Drugs / interventions tested

Cardiac surgery

Conditions studied

Acute Kidney Injury — all drugs for Acute Kidney Injury →

Sponsor

Medical University of Vienna

Who can join

18 and older, any sex, with Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators want to investigate if the urinary biomarker neprilysin can identify cardiac surgical patients suffering from postoperative AKI within 24 hours.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study.
Bernardi MH, Wagner L, Ryz S, Puchinger J, et al · · 2021 · cited 8× · PMID 32941200 · DOI 10.1097/eja.0000000000001321

Verify or expand the search:

Other trials of Cardiac surgery

Trials testing the same drug.

NCT06958029 — Postoperative Atrial Fibrillation in Cardiac Surgery · recruiting
NCT06175650 — Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway: · recruiting
NCT06078410 — Neurologic Evaluation of Patients After Transapical Beating-Heart Septal Myectomy · unknown
NCT06554925 — SEx-specific Differences in Cardiac Surgery Patients (SECS). · recruiting
NCT04487262 — Timing for Removal of Chest Tubes in Adult Cardiac Surgery · NA · terminated

Other recruiting trials for Acute Kidney Injury

Currently open trials in the same condition.

NCT07273838 — Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome · Phase 2 · recruiting
NCT07262320 — Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America · recruiting
NCT07351149 — Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery · recruiting
NCT07215702 — A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kid · Phase 2 · recruiting
NCT06654193 — Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury · Phase 1, PHASE2 · recruiting

Other Medical University of Vienna trials

Trials by the same sponsor.

NCT07473401 — Retinal Oxygen Metabolism in Children With Myopia · not yet recruiting
NCT07511400 — The Role of NaV1.8 in Human Pain Models · EARLY_PHASE1 · not yet recruiting
NCT07516990 — Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoper · NA · recruiting
NCT07496437 — Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? · NA · not yet recruiting
NCT07290712 — Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03854825 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
Last refreshed: 22 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03854825.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing