NCT03850041 is a clinical trial in Obstructive Sleep Apnea, sponsored by University Health Network, Toronto.

Who is sponsoring NCT03850041?

NCT03850041 is sponsored by University Health Network, Toronto.

What condition does NCT03850041 study?

NCT03850041 studies Obstructive Sleep Apnea.

Is NCT03850041 still recruiting?

NCT03850041 is currently terminated. Last updated 23 June 2022.

Last reviewed 2022-06-23 · How we verify

NCT03850041

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Fluid Volume Shifts on Upper Airway Collapse and Obstructive Sleep Apnea in Surgical Patients

Terminated Last updated 23 June 2022

What this trial tests

trial in Obstructive Sleep Apnea in 50 participants. Terminated before completion.

Timeline

22 July 2019

Primary endpoint
14 December 2020

14 December 2020

Quick facts

Lead sponsor	University Health Network, Toronto
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	50
Start date	22 July 2019
Primary completion	14 December 2020
Estimated completion	14 December 2020
Sites	2 locations across Canada

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

University Health Network, Toronto

Who can join

18 and older, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to examine the contribution of intravenous (IV) fluid administration and rostral fluid shift from the legs to the neck thereby leading to worsening of sleep apnea following surgery. In this prospective, observational cohort study, 50 consecutive preoperative adult obstructive sleep apnea (OSA) patients, requiring at least one night hospital stay post surgery, will be recruited. Recent research from general population suggests that intravenous (IV) fluid administration worsens the severity of OSA by shifting of fluid from the legs to the neck thus increasing neck size and causing airway collapse. The results of this study will be used to design future clinical trials evaluating methods to decrease postoperative OSA worsening, as well as decreasing OSA-related postoperative complications.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Perioperative trends in neck and leg fluid volume in surgical patients: a prospective observational proof-of-concept study.
Lukachan GA, Chung F, Yadollahi A, Auckley D, et al · · 2023 · cited 2× · PMID 36450944 · DOI 10.1007/s12630-022-02362-6

Verify or expand the search:

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

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Other University Health Network, Toronto trials

Trials by the same sponsor.

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NCT07509450 — Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cel · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03850041 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Health Network, Toronto
Last refreshed: 23 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03850041.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing