Who is sponsoring NCT03846830?

NCT03846830 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT03846830?

Interventions in NCT03846830: Incremental Velocity Error (IVE), Traditional Vestibular Rehabilitation (VPT).

What condition does NCT03846830 study?

NCT03846830 studies Mild Traumatic Brain Injury, Vestibular Neuropathy.

Is NCT03846830 still recruiting?

NCT03846830 is currently completed. Last updated 12 November 2025.

Last reviewed 2025-11-12 · How we verify

NCT03846830: INVENT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation

Completed NA Last updated 12 November 2025

What this trial tests

NA trial testing Incremental Velocity Error (IVE) in Mild Traumatic Brain Injury in 24 participants. Completed in 1 April 2025.

Timeline

11 October 2021

Primary endpoint
1 April 2025

1 April 2025

Quick facts

Lead sponsor	Johns Hopkins University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	24
Start date	11 October 2021
Primary completion	1 April 2025
Estimated completion	1 April 2025
Sites	2 locations across United States

Drugs / interventions tested

Incremental Velocity Error (IVE)
Traditional Vestibular Rehabilitation (VPT)

Conditions studied

Mild Traumatic Brain Injury — all drugs for Mild Traumatic Brain Injury →
Vestibular Neuropathy — all drugs for Vestibular Neuropathy →

Sponsor

Johns Hopkins University

Who can join

18 and older, any sex, with Mild Traumatic Brain Injury or Vestibular Neuropathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective for this study is to compare outcome measures from vestibular rehabilitation (VPT) delivered in a traditional method against a new device Incremental Velocity Error (IVE) that improves physiologic performance of the vestibulo-ocular reflex. Participants include active duty service members with mild traumatic brain injury (mTBI) and civilians with peripheral vestibular hypofunction. The investigators will use a clinical trial cross-over design with randomization to either the control (VPT) or experimental (IVE) group and measure vestibulo-ocular reflex function as well as subjective and functional outcomes in order to investigate the best means to improve delivery of vestibular rehabilitation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation (INVENT VPT) Trial: study protocol for a randomized controlled crossover trial.
Ervin AM, Schubert MC, Migliaccio AA, Perin J, et al · · 2021 · cited 2× · PMID 34895314 · DOI 10.1186/s13063-021-05876-4
Incremental Velocity Error As A New Treatment In Vestibular Rehabilitation (INVENT VPT Trial): Study Protocol For A Randomized Controlled Crossover Trial
Ervin AM, Schubert M, Migliaccio A, Perin J, et al · · 2021 · DOI 10.21203/rs.3.rs-434974/v1

Verify or expand the search:

Other recruiting trials for Mild Traumatic Brain Injury

Currently open trials in the same condition.

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NCT07356167 — Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury · NA · recruiting
NCT07097792 — Concussion Recovery and Support Program · NA · recruiting
NCT06956417 — REhabilitation of MEMory Symptoms After BRain Concussion · NA · recruiting
NCT06217575 — Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans · NA · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03846830 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 12 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03846830.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing