NCT03846544 (DUOPICK) is a Phase 4 clinical trial of Corifollitoropin alfa (CFA)-double pick up in Fertility Disorders, sponsored by CRG UZ Brussel.

Who is sponsoring NCT03846544?

NCT03846544 is sponsored by CRG UZ Brussel.

What drugs are being tested in NCT03846544?

Interventions in NCT03846544: Corifollitoropin alfa (CFA)-double pick up.

What condition does NCT03846544 study?

NCT03846544 studies Fertility Disorders.

Is NCT03846544 still recruiting?

NCT03846544 is currently completed. Last updated 21 May 2024.

Are results published for NCT03846544?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2024-05-21 · How we verify

NCT03846544: DUOPICK

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Double Pick up in Poor Prognosis Women

Completed Phase 4 Results posted Last updated 21 May 2024

What this trial tests

Phase 4 trial testing Corifollitoropin alfa (CFA)-double pick up in Fertility Disorders in 48 participants. Completed in 1 October 2022.

Timeline

1 October 2019

Primary endpoint
15 September 2021

1 October 2022

Quick facts

Lead sponsor	CRG UZ Brussel
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	48
Start date	1 October 2019
Primary completion	15 September 2021
Estimated completion	1 October 2022
Sites	1 location across Belgium

Drugs / interventions tested

Corifollitoropin alfa (CFA)-double pick up — full drug profile →

Conditions studied

Fertility Disorders — all drugs for Fertility Disorders →

Sponsor

CRG UZ Brussel — full company profile →

Who can join

Adults 25 to 40, female only, with Fertility Disorders. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of MII Oocytes Retrieved Between the Two Arms Primary · 1 month

number of mature (or metaphase II, MII) oocytes retrieved during oocyte retrieval

Group	Value	95% CI
Control Group	4.1	± 2.4
Double Pick up Group	3.0	± 2.2

Number of Preovulatory Follicles Secondary · 1 month

number of follicles ≥11m on the day of final oocyte maturation trigger

Group	Value	95% CI
Control Group	5.4	± 2.2
Double Pick up Group	5.0	± 1.6

Number of Cumulus Oocyte Complexes (COCs) Retrieved Secondary · 1 month

number of COCs retrieved at oocyte retrieval

Group	Value	95% CI
Control Group	5.3	± 2.7
Double Pick up Group	3.3	± 2.2

Number of Oocytes Fertilized Secondary · 1 month

number of fertilized oocytes at day 1 after oocyte retrieval

Group	Value	95% CI
Control Group	3.7	± 2.4
Double Pick up Group	2.3	± 2.0

Total Number of Available Embryos Secondary · 1 month

number of available embryos at day 3 or day 5 after oocyte retrieval, good quality and therefore transferable

Group	Value	95% CI
Control Group	1.5	± 0.9
Double Pick up Group	1.4	± 1.3

Duration of Ovarian Stimulation Secondary · 1 month

number of days of ovarian stimulation

Group	Value	95% CI
Control Group	9.9	± 2.7
Double Pick up Group	9.9	± 3.0

Clinical Pregnancy Rates Secondary · 4 months

clinical pregnancy rate

Group	Value	95% CI
Control Group	7
Double Pick up Group	13

Live Birth Rates Secondary · 12 months

number of live births

Group	Value	95% CI
Control Group	6
Double Pick up Group	8

Sponsor's own description

The purpose of this randomized pilot study is to compare the efficacy of double oocyte retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients undergoing in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Does dual oocyte retrieval with continuous FSH administration increase the number of mature oocytes in low responders? An open-label randomized controlled trial.
Boudry L, Mateizel I, Wouters K, Papaleo E, et al · · 2024 · cited 5× · PMID 38199789 · DOI 10.1093/humrep/dead276

Verify or expand the search:

Other recruiting trials for Fertility Disorders

Currently open trials in the same condition.

NCT07017972 — Data Collection and Professional Simulated Use Study to Develop an Embryo Quality Artificial Intelligence (AI) Model · recruiting
NCT06928337 — Data Collection Protocol for the Development of CHLOE-OQ, an AI Model for Assessing Oocytes Quality. · recruiting
NCT06799507 — The Effect of Mindfulness-Based Lifestyle Support Program on Infertile Women · NA · recruiting
NCT04663971 — Fertility and Pregnancy After Surgery IBD Audit · recruiting
NCT05725512 — Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages · Phase 4 · recruiting

Other CRG UZ Brussel trials

Trials by the same sponsor.

NCT05405686 — Effect of LH Supplementation on the Endometrial Gene Expression Profile in Poor Ovarian Responders · Phase 4 · withdrawn
NCT05521828 — Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone · NA · unknown
NCT05746793 — At High-risk for Pre-eclampsia After Assisted Reproductive Technology · recruiting
NCT04997070 — Sperm Selection Using Microfluidic Technology · completed
NCT04758871 — Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles · Phase 4 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03846544 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by CRG UZ Brussel
Last refreshed: 21 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03846544.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing