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NCT04997070: MSS
Sperm Selection Using Microfluidic Technology
trial in Infertility, Male in 1,038 participants. Completed in 1 March 2024.
1 March 2024
Quick facts
| Lead sponsor | CRG UZ Brussel |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,038 |
| Start date | 16 May 2022 |
| Primary completion | 1 March 2024 |
| Estimated completion | 1 March 2024 |
| Sites | 1 location across Belgium |
Conditions studied
- Infertility, Male — all drugs for Infertility, Male →
Sponsor
CRG UZ Brussel — full company profile →
Who can join
Adults 18 to 43, any sex, with Infertility, Male. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction. This is a technique that is already used in other centres. The Microfluidic Sperm Sorting (MSS) technology reduces the time of sample preparation while selects a sperm population with better motility and less DNA fragmentation as compared to routine procedures. This med-ical device is already CE marked. Having the intention to implement this technology in our department, we conduct this study to investigate whether the use of MSS has at least the same impact, if not better, on fertilization and embryo quality as compared to standard sperm selection procedures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Microfluidics for in vitro fertilization: from science to clinical validation.
Pensabene V, Agate F, Santos Miranda A, Picton HM. · · 2026 · PMID 41349964 · DOI 10.1093/humupd/dmaf028
Verify or expand the search:
- PubMed search for NCT04997070
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Infertility, Male
Currently open trials in the same condition.
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- NCT05514223 — Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors · recruiting
- NCT06841861 — Spermatogonial Differentiation Via Testicular Organoid · Phase 1, PHASE2 · recruiting
- NCT05903859 — Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) · Phase 3 · recruiting
Other CRG UZ Brussel trials
Trials by the same sponsor.
- NCT05405686 — Effect of LH Supplementation on the Endometrial Gene Expression Profile in Poor Ovarian Responders · Phase 4 · withdrawn
- NCT05521828 — Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone · NA · unknown
- NCT05746793 — At High-risk for Pre-eclampsia After Assisted Reproductive Technology · recruiting
- NCT04758871 — Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles · Phase 4 · completed
- NCT04665102 — Pilot Study on Deep Learning in the Eye · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04997070 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CRG UZ Brussel
- Last refreshed: 6 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04997070.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing