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NCT03838107
Markers of Trajectory in Pediatric CRPS
trial testing observation and measure of trajectory of recovery in CRPS in Complex Regional Pain Syndromes in 126 participants. Currently enrolling.
31 August 2026
Quick facts
| Lead sponsor | Children's Hospital Medical Center, Cincinnati |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 126 |
| Start date | 27 August 2018 |
| Primary completion | 31 August 2026 |
| Estimated completion | 31 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- observation and measure of trajectory of recovery in CRPS
Conditions studied
- Complex Regional Pain Syndromes — all drugs for Complex Regional Pain Syndromes →
Sponsor
Children's Hospital Medical Center, Cincinnati
Who can join
Adults 10 to 17, any sex, with Complex Regional Pain Syndromes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Complex Regional Pain Syndrome (CRPS) is a severe and complex chronic pain condition in children. Many psychosocial factors impact its development and recovery. CRPS has a strong central component, which is reflected by structural and functional changes in the brain. However, the interaction between these cerebral changes and trajectory of recovery has been seldom investigated to date. Furthermore, interactions between cerebral changes and psychosocial factors, which might affect trajectory of recovery, are unknown. The aim of this study is to identify the psychosocial factors and cerebral changes that predict the trajectory of recovery from CRPS. Children between the ages of 10 and 17 years will be enrolled with one of their parents or legal guardians for this study. Three populations will be recruited: patients with CRPS undergoing treatment at the Functional Independence Restoration Program (FIRST), patients with CRPS undergoing treatment at the Pain Management Center and matching healthy controls. Participants will undergo three sessions: the first session will be scheduled immediately before or as soon as possible at the beginning of the patients' treatment; the second session will take place at the end of the patients' treatment; the last session will be scheduled six months post-treatment. The timing of the sessions of the healthy participants will follow a schedule similar to the FIRST patients. Each session will last approximately three hours and include acquisition of psychosocial, psychophysical, and brain imaging data in the child participants, as well as acquisition of psychosocial data in the parent participants.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03838107
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other recruiting trials for Complex Regional Pain Syndromes
Currently open trials in the same condition.
- NCT05986461 — Spatially Transcriptomics Reveals Molecular Signatures in CRPS · recruiting
- NCT05814497 — Supraspinal Processing of Sensory Aspects of Pain · NA · recruiting
- NCT05593237 — Transcranial Magnetic Stimulation for Chronic Neuropathic Pain · NA · active not recruiting
- NCT05337501 — Prognostic Factors for Complex Regional Pain Syndrome · NA · active not recruiting
- NCT04144972 — Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain · NA · recruiting
Other Children's Hospital Medical Center, Cincinnati trials
Trials by the same sponsor.
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- NCT07217444 — Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03838107 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati
- Last refreshed: 7 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03838107.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing