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NCT03823508
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
NA trial testing anodal tDCS in Vegetative State in 15 participants. Completed in 1 June 2019.
1 June 2019
Quick facts
| Lead sponsor | University of Liege |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 15 |
| Start date | 1 January 2018 |
| Primary completion | 1 June 2019 |
| Estimated completion | 1 June 2019 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- anodal tDCS
- sham tDCS
Conditions studied
- Vegetative State — all drugs for Vegetative State →
- Minimally Conscious State — all drugs for Minimally Conscious State →
- Disorder of Consciousness — all drugs for Disorder of Consciousness →
Sponsor
University of Liege
Who can join
Adults 16 to 75, any sex, with Vegetative State or Minimally Conscious State. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved to be effective in improving signs of consciousness in about 50% of patients in MCS either after a single stimulation or after repeated sessions. However, brain mechanisms underlying tDCS effects remain poorly understood. Here we aim to assess the effects of prefrontal tDCS on neurophysiological (i.e., electroencephalography - EEG - primary outcome) and behavioral (secondary outcome) measures in severely brain-injured patients with DOC.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03823508
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of anodal tDCS
Trials testing the same drug.
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- NCT03185234 — Rehabilitating (Stroke-induced) Apraxia With Direct Current Stimulation · NA · completed
Other recruiting trials for Vegetative State
Currently open trials in the same condition.
- NCT04065386 — Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness · NA · active not recruiting
Other University of Liege trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03823508 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Liege
- Last refreshed: 17 July 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03823508.
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