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NCT03810859: EXODENT
Non-syndromic Inherited Anomalies of Mineralized Tooth Tissues: a Whole Exome Study to Identify New Pathogenic Variants
NA trial testing Blood sample in Amelogenesis Imperfecta in 14 participants. Status unknown.
15 September 2022
Quick facts
| Lead sponsor | Assistance Publique - Hôpitaux de Paris |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 14 |
| Start date | 9 October 2019 |
| Primary completion | 15 September 2022 |
| Estimated completion | 15 September 2022 |
| Sites | 1 location across France |
Drugs / interventions tested
- Blood sample — full drug profile →
Conditions studied
- Amelogenesis Imperfecta — all drugs for Amelogenesis Imperfecta →
- Dentinogenesis Imperfecta — all drugs for Dentinogenesis Imperfecta →
- Dentin Anomalies — all drugs for Dentin Anomalies →
Sponsor
Assistance Publique - Hôpitaux de Paris — full company profile →
Who can join
4 and older, any sex, with Amelogenesis Imperfecta or Dentinogenesis Imperfecta. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
ExoDent specifically aims to discover new genes and new mutations causing isolated amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) and other dentin anomalies. The key point for clinicians is to distinguish between non syndromic and syndromic disorders in order to improve patients guidance and counseling. To do so, two targeted NGS panel have been designed, one searching for isolated AI and the other for DI. After 18 months, some families remain without any positive results. ExoDent project proposes those negative patients a Whole Exome Sequencing (WES) approach to deeper explore their genetic background.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03810859
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Amelogenesis Imperfecta
Currently open trials in the same condition.
- NCT07250906 — Oral Health Related Quality of Life of Children With Amelogenesis Imperfecta · recruiting
- NCT04704089 — Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects · recruiting
Other Assistance Publique - Hôpitaux de Paris trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03810859 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
- Last refreshed: 22 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03810859.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing